Inhalable chitosan nanoparticles as antitubercular drug carriers for an effective treatment of tuberculosis

Tarun Garg; Goutam Rath; Amit K. Goyal

doi:10.3109/21691401.2015.1008508

Inhalable chitosan nanoparticles as antitubercular drug carriers for an effective treatment of tuberculosis

Tarun Garg, Goutam Rath, Amit K. Goyal

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

The aim of this study was to prepare and characterize spray dried inhalable chitosan nanoparticles (CNPs) for sustained delivery of anti-tubercular drugs, isoniazid (INH) and rifampicin (RIF), to the lungs. CNPs were prepared by ionic gelation technique followed spray drying. Results showed that the CNPs obtained had a smooth spherical shape with an average size of 230 ± 4.5 nm, with a poly dispersity index of 0.180 ± 0.021. Both drugs, were detected in various organs (lungs, liver, spleen and kidney) until 24 h post nebulization. The chemotherapeutic efficacy of a single dose of drug-loaded CNPs suggested that they are more effective against the mycobacterium than free drugs.

Original language	English (US)
Pages (from-to)	997-1001
Number of pages	5
Journal	Artificial Cells, Nanomedicine and Biotechnology
Volume	44
Issue number	3
DOIs	https://doi.org/10.3109/21691401.2015.1008508
State	Published - Apr 2 2016
Externally published	Yes

ASJC Scopus subject areas

Biotechnology
Biomedical Engineering
Pharmaceutical Science
Medicine (miscellaneous)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3109/21691401.2015.1008508

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abstract = "The aim of this study was to prepare and characterize spray dried inhalable chitosan nanoparticles (CNPs) for sustained delivery of anti-tubercular drugs, isoniazid (INH) and rifampicin (RIF), to the lungs. CNPs were prepared by ionic gelation technique followed spray drying. Results showed that the CNPs obtained had a smooth spherical shape with an average size of 230 ± 4.5 nm, with a poly dispersity index of 0.180 ± 0.021. Both drugs, were detected in various organs (lungs, liver, spleen and kidney) until 24 h post nebulization. The chemotherapeutic efficacy of a single dose of drug-loaded CNPs suggested that they are more effective against the mycobacterium than free drugs.",

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AU - Rath, Goutam

AU - Goyal, Amit K.

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Inhalable chitosan nanoparticles as antitubercular drug carriers for an effective treatment of tuberculosis

Abstract

ASJC Scopus subject areas

UN SDGs

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