@article{b4af16b8a5fe4877b5cd728eec975e58,
title = "Interaction between transforming Theileria parasites and their host bovine leukocytes",
abstract = "Theileria are tick-transmitted parasites that cause often fatal leuko-proliferative diseases in cattle called tropical theileriosis (T. annulata) and East Coast fever (T. parva). However, upon treatment with anti-theilerial drug-transformed leukocytes die of apoptosis indicating that Theileria-induced transformation is reversible making infected leukocytes a powerful example of how intracellular parasites interact with their hosts. Theileria-transformed leukocytes disseminate throughout infected cattle causing a cancer-like disease and here, we discuss how cytokines, noncoding RNAs and oncometabolites can contribute to the transformed phenotype and disease pathology.",
author = "Shahin Tajeri and Malak Haidar and Takaya Sakura and Gordon Langsley",
note = "KAUST Repository Item: Exported on 2021-02-15 Acknowledged KAUST grant number(s): OSR-2015-CRG4-2610 Acknowledgements: ST and TS acknowledge postdoctoral fellowships from ParaFrap (ANR-11-LABX-0024) and MH postdoctoral funding from a Competitive Research Grant from the Office for Sponsored Research (OSR-2015-CRG4-2610) at King Abdullah University of Science and Technology (KAUST) awarded to Arnab Pain and GL. The RNAseq data in Figure 2 were generated by MH, while a post-doc in Arnab Pain{\textquoteright}s laboratory. GL also acknowledges ANR-11-LABX-0024 and core support from INSERM and the CNRS.",
year = "2021",
month = feb,
day = "9",
doi = "10.1111/mmi.14642",
language = "English (US)",
journal = "Molecular Microbiology",
issn = "0950-382X",
publisher = "Wiley-Blackwell",
}
