Interrelatedness between C-reactive protein and oxidized low-density lipoprotein

M.M. Obradovic; A. Trpkovic; V. Bajic; S. Soskic; A. Jovanovic; J. Stanimirovic; M. Panic; E.R. Isenovic

doi:10.1515/cclm-2014-0590

Interrelatedness between C-reactive protein and oxidized low-density lipoprotein

M.M. Obradovic, A. Trpkovic, V. Bajic, S. Soskic, A. Jovanovic, J. Stanimirovic, M. Panic, E.R. Isenovic

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

© De Gruyter 2015.C-reactive protein (CRP) is a marker of inflammation. Atherosclerosis is now recognized as inflammatory disease, and it seems that CRP directly contributes to atherogenesis. Oxidation of low-density lipoprotein (LDL) molecule increases the uptake of lipid products by macrophages leading to cholesterol accumulation and subsequent foam cell formation. The elevated levels of high sensitivity CRP (hsCRP) and oxidized LDL (OxLDL) in the blood were found to be associated with cardiovascular diseases (CVD). In this review, we highlighted the evidence that CRP and OxLDL are involved in interrelated (patho) physiological pathways. The findings on association between hsCRP and OxLDL in the clinical setting will be also summarized.

Original language	English (US)
Journal	Clinical Chemistry and Laboratory Medicine
Volume	53
Issue number	1
DOIs	https://doi.org/10.1515/cclm-2014-0590
State	Published - 2015

Keywords

[C-reactive protein (CRP), C-reactive protein and

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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http://www.mendeley.com/research/interrelatedness-between-creactive-protein-oxidized-lowdensity-lipoprotein-3

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title = "Interrelatedness between C-reactive protein and oxidized low-density lipoprotein",

abstract = "{\textcopyright} De Gruyter 2015.C-reactive protein (CRP) is a marker of inflammation. Atherosclerosis is now recognized as inflammatory disease, and it seems that CRP directly contributes to atherogenesis. Oxidation of low-density lipoprotein (LDL) molecule increases the uptake of lipid products by macrophages leading to cholesterol accumulation and subsequent foam cell formation. The elevated levels of high sensitivity CRP (hsCRP) and oxidized LDL (OxLDL) in the blood were found to be associated with cardiovascular diseases (CVD). In this review, we highlighted the evidence that CRP and OxLDL are involved in interrelated (patho) physiological pathways. The findings on association between hsCRP and OxLDL in the clinical setting will be also summarized.",

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doi = "10.1515/cclm-2014-0590",

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T1 - Interrelatedness between C-reactive protein and oxidized low-density lipoprotein

AU - Obradovic, M.M.

AU - Trpkovic, A.

AU - Bajic, V.

AU - Soskic, S.

AU - Jovanovic, A.

AU - Stanimirovic, J.

AU - Panic, M.

AU - Isenovic, E.R.

PY - 2015

Y1 - 2015

N2 - © De Gruyter 2015.C-reactive protein (CRP) is a marker of inflammation. Atherosclerosis is now recognized as inflammatory disease, and it seems that CRP directly contributes to atherogenesis. Oxidation of low-density lipoprotein (LDL) molecule increases the uptake of lipid products by macrophages leading to cholesterol accumulation and subsequent foam cell formation. The elevated levels of high sensitivity CRP (hsCRP) and oxidized LDL (OxLDL) in the blood were found to be associated with cardiovascular diseases (CVD). In this review, we highlighted the evidence that CRP and OxLDL are involved in interrelated (patho) physiological pathways. The findings on association between hsCRP and OxLDL in the clinical setting will be also summarized.

AB - © De Gruyter 2015.C-reactive protein (CRP) is a marker of inflammation. Atherosclerosis is now recognized as inflammatory disease, and it seems that CRP directly contributes to atherogenesis. Oxidation of low-density lipoprotein (LDL) molecule increases the uptake of lipid products by macrophages leading to cholesterol accumulation and subsequent foam cell formation. The elevated levels of high sensitivity CRP (hsCRP) and oxidized LDL (OxLDL) in the blood were found to be associated with cardiovascular diseases (CVD). In this review, we highlighted the evidence that CRP and OxLDL are involved in interrelated (patho) physiological pathways. The findings on association between hsCRP and OxLDL in the clinical setting will be also summarized.

KW - [C-reactive protein (CRP), C-reactive protein and

U2 - 10.1515/cclm-2014-0590

DO - 10.1515/cclm-2014-0590

M3 - Article

C2 - 25010779

SN - 1434-6621

VL - 53

JO - Clinical Chemistry and Laboratory Medicine

JF - Clinical Chemistry and Laboratory Medicine

IS - 1

ER -

Interrelatedness between C-reactive protein and oxidized low-density lipoprotein

Abstract

Keywords

UN SDGs

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