Intramolecular Electrochemical Oxybromination of Olefins for the Synthesis of Isoxazolines in Batch and Continuous Flow

Ajit Prabhakar Kale; Pavlo Nikolaienko; Kristina Smirnova; Magnus Rueping

doi:10.1002/ejoc.202100640

Intramolecular Electrochemical Oxybromination of Olefins for the Synthesis of Isoxazolines in Batch and Continuous Flow

Ajit Prabhakar Kale, Pavlo Nikolaienko, Kristina Smirnova, Magnus Rueping

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

A new electrochemical method for the synthesis of 2-isoxazolines is reported. The reaction operates under atmospheric conditions and tolerates air and moisture. The use of potassium bromide as both electrolyte and bromine source precludes the need for toxic, air-sensitive inorganic oxidants or transition metal catalysts.

Original language	English (US)
Pages (from-to)	3496-3500
Number of pages	5
Journal	European Journal of Organic Chemistry
Volume	2021
Issue number	24
DOIs	https://doi.org/10.1002/ejoc.202100640
State	Published - Jun 23 2021

ASJC Scopus subject areas

Organic Chemistry
Physical and Theoretical Chemistry

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10.1002/ejoc.202100640

https://repository.kaust.edu.sa/bitstream/10754/669774/1/Manuscript-accepted.pdf

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title = "Intramolecular Electrochemical Oxybromination of Olefins for the Synthesis of Isoxazolines in Batch and Continuous Flow",

abstract = "A new electrochemical method for the synthesis of 2-isoxazolines is reported. The reaction operates under atmospheric conditions and tolerates air and moisture. The use of potassium bromide as both electrolyte and bromine source precludes the need for toxic, air-sensitive inorganic oxidants or transition metal catalysts.",

author = "{Prabhakar Kale}, Ajit and Pavlo Nikolaienko and Kristina Smirnova and Magnus Rueping",

note = "KAUST Repository Item: Exported on 2021-06-25 Acknowledgements: This work was financially supported by the King Abdullah University of Science and Technology (KAUST), Saudi Arabia.",

year = "2021",

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doi = "10.1002/ejoc.202100640",

language = "English (US)",

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journal = "European Journal of Organic Chemistry",

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T1 - Intramolecular Electrochemical Oxybromination of Olefins for the Synthesis of Isoxazolines in Batch and Continuous Flow

AU - Prabhakar Kale, Ajit

AU - Nikolaienko, Pavlo

AU - Smirnova, Kristina

AU - Rueping, Magnus

N1 - KAUST Repository Item: Exported on 2021-06-25 Acknowledgements: This work was financially supported by the King Abdullah University of Science and Technology (KAUST), Saudi Arabia.

PY - 2021/6/23

Y1 - 2021/6/23

N2 - A new electrochemical method for the synthesis of 2-isoxazolines is reported. The reaction operates under atmospheric conditions and tolerates air and moisture. The use of potassium bromide as both electrolyte and bromine source precludes the need for toxic, air-sensitive inorganic oxidants or transition metal catalysts.

AB - A new electrochemical method for the synthesis of 2-isoxazolines is reported. The reaction operates under atmospheric conditions and tolerates air and moisture. The use of potassium bromide as both electrolyte and bromine source precludes the need for toxic, air-sensitive inorganic oxidants or transition metal catalysts.

UR - http://hdl.handle.net/10754/669774

UR - https://onlinelibrary.wiley.com/doi/10.1002/ejoc.202100640

U2 - 10.1002/ejoc.202100640

DO - 10.1002/ejoc.202100640

M3 - Article

SN - 1434-193X

VL - 2021

SP - 3496

EP - 3500

JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

IS - 24

ER -

Intramolecular Electrochemical Oxybromination of Olefins for the Synthesis of Isoxazolines in Batch and Continuous Flow

Abstract

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