IPS cells forgive but do not forget

Maria J. Barrero; Juan Carlos Izpisua Belmonte

doi:10.1038/ncb0511-523

IPS cells forgive but do not forget

Maria J. Barrero, Juan Carlos Izpisua Belmonte

Research output: Contribution to journal › Short survey › peer-review

14 Scopus citations

Abstract

Induced pluripotent stem (iPS) cells offer the possibility to generate patient-specific cell types for use in regenerative medicine. However, a long-lasting question remains: are iPS and embryonic stem cells equivalent? iPS cells retain a transcriptional memory of their origin, which is now shown to endure with passages and to correlate with defects in the re-establishment of DNA methylation. Both selective pressure and genomic environment may account for these defects.

Original language	English (US)
Pages (from-to)	523-525
Number of pages	3
Journal	Nature Cell Biology
Volume	13
Issue number	5
DOIs	https://doi.org/10.1038/ncb0511-523
State	Published - May 2011
Externally published	Yes

ASJC Scopus subject areas

Cell Biology

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10.1038/ncb0511-523

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title = "IPS cells forgive but do not forget",

abstract = "Induced pluripotent stem (iPS) cells offer the possibility to generate patient-specific cell types for use in regenerative medicine. However, a long-lasting question remains: are iPS and embryonic stem cells equivalent? iPS cells retain a transcriptional memory of their origin, which is now shown to endure with passages and to correlate with defects in the re-establishment of DNA methylation. Both selective pressure and genomic environment may account for these defects.",

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AB - Induced pluripotent stem (iPS) cells offer the possibility to generate patient-specific cell types for use in regenerative medicine. However, a long-lasting question remains: are iPS and embryonic stem cells equivalent? iPS cells retain a transcriptional memory of their origin, which is now shown to endure with passages and to correlate with defects in the re-establishment of DNA methylation. Both selective pressure and genomic environment may account for these defects.

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DO - 10.1038/ncb0511-523

M3 - Short survey

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VL - 13

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JO - Nature Cell Biology

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IPS cells forgive but do not forget

Abstract

ASJC Scopus subject areas

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