TY - JOUR
T1 - IPSC technology to study human aging and aging-related disorders
AU - Liu, Guang Hui
AU - Ding, Zhichao
AU - Izpisua Belmonte, Juan Carlos
PY - 2012/12
Y1 - 2012/12
N2 - A global aging population, normally accompanied by a high incidence of aging-associated diseases, has prompted a renewed interest in basic research on human aging. Although encouraging progress has been achieved using animal models, the underlying fundamental mechanisms of aging remain largely unknown. Here, we review the human induced pluripotent stem cell (hiPSC)-based models of aging and aging-related diseases. These models seek to advance our knowledge of aging molecular mechanisms and help to develop strategies for treating aging-associated human diseases.
AB - A global aging population, normally accompanied by a high incidence of aging-associated diseases, has prompted a renewed interest in basic research on human aging. Although encouraging progress has been achieved using animal models, the underlying fundamental mechanisms of aging remain largely unknown. Here, we review the human induced pluripotent stem cell (hiPSC)-based models of aging and aging-related diseases. These models seek to advance our knowledge of aging molecular mechanisms and help to develop strategies for treating aging-associated human diseases.
UR - http://www.scopus.com/inward/record.url?scp=84871936169&partnerID=8YFLogxK
U2 - 10.1016/j.ceb.2012.08.014
DO - 10.1016/j.ceb.2012.08.014
M3 - Review article
C2 - 22999273
AN - SCOPUS:84871936169
SN - 0955-0674
VL - 24
SP - 765
EP - 774
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 6
ER -
