Abstract
A new catalytic enantioselective hydroarylation of unactivated olefins provides rapid access to functionalized chiral dihydrobenzofurans with good yields and excellent enantio-selectivities. Simple aromatic ketones or amides act as directing group allowing the regioselective reaction at the more hindered ortho position. Tertiary benzylic stereocenters are obtained directly under mild reaction conditions and with complete atom economy from readily available starting materials.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 8308-8313 |
| Number of pages | 6 |
| Journal | Chemistry (Weinheim an der Bergstrasse, Germany) |
| Volume | 26 |
| Issue number | 37 |
| DOIs | |
| State | Published - Apr 18 2020 |
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Dive into the research topics of 'Iridium (I)-Catalyzed Enantioselective Hydroarylation of Alkenes via C-H bond Activation: Experiment and Computation.'. Together they form a unique fingerprint.Datasets
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CCDC 1877011: Experimental Crystal Structure Determination : 1-(3-benzyl-5-bromo-2,3-dihydro-1-benzofuran-4-yl)ethan-1-one
Rueping, M. (Creator), Shinde, V. (Creator), Mane, M. V. (Creator) & Cavallo, L. (Creator), Cambridge Crystallographic Data Centre, Nov 8 2018
DOI: 10.5517/ccdc.csd.cc2105r0, http://hdl.handle.net/10754/665102
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