Iron catalysed cross-couplings of azetidines-application to the formal synthesis of a pharmacologically active molecule

Dixit Parmar; Lena Henkel; Josef Dib; Magnus Rueping

doi:10.1039/c4cc09337b

Iron catalysed cross-couplings of azetidines-application to the formal synthesis of a pharmacologically active molecule

Dixit Parmar, Lena Henkel, Josef Dib, Magnus Rueping^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

A protocol for the coupling of 3-iodoazetidines with Grignard reagents in the presence of an iron catalyst has been developed. A variety of aryl, heteroaryl, vinyl and alkyl Grignards were shown to participate in the coupling process to give the products in good to excellent yields. Furthermore, a short formal synthesis towards a pharmacologically active molecule was shown.

Original language	English (US)
Pages (from-to)	2111-2113
Number of pages	3
Journal	CHEMICAL COMMUNICATIONS
Volume	51
Issue number	11
DOIs	https://doi.org/10.1039/c4cc09337b
State	Published - Feb 7 2015
Externally published	Yes

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
General Chemistry
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Catalysis

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AU - Henkel, Lena

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AU - Rueping, Magnus

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AB - A protocol for the coupling of 3-iodoazetidines with Grignard reagents in the presence of an iron catalyst has been developed. A variety of aryl, heteroaryl, vinyl and alkyl Grignards were shown to participate in the coupling process to give the products in good to excellent yields. Furthermore, a short formal synthesis towards a pharmacologically active molecule was shown.

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Iron catalysed cross-couplings of azetidines-application to the formal synthesis of a pharmacologically active molecule

Abstract

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