TY - JOUR
T1 - Iron Single-Atom Catalysts on MXenes for Ultrasensitive Monitoring of Adrenal Tumor Markers and Cellular Dopamine
AU - Shetty, Saptami Suresh
AU - El-Demellawi, Jehad K.
AU - Khan, Yusuf
AU - Hedhili, Mohamed N.
AU - Arul, P.
AU - Mani, Veerappan
AU - Alshareef, Husam N.
AU - Salama, Khaled Nabil
N1 - Funding Information:
This work was supported financially by King Abdullah University of Science and Technology (KAUST), Saudi Arabia. In addition, the authors acknowledge the funding from the KAUST smart health initiative.
Publisher Copyright:
© 2023 Wiley-VCH GmbH.
PY - 2023/3/24
Y1 - 2023/3/24
N2 - Neuroblastoma and pheochromocytoma are the most prevalent malignancies of the adrenal medulla. They are currently diagnosed by measuring urinary catecholamines using high-performance liquid chromatography-mass spectrometry, which is expensive, bulky, and tedious. Electrochemical detectors stand out as low-cost alternatives; however, further development of functional materials with adequate sensitivity is still required to attain clinically useful diagnostic devices. Here, Ti3C2Tx MXene nanosheets stabilized with iron single-atom catalysts (Fe-SACs), anchored on the surface, are synthesized and utilized as efficient electrocatalysts for the determination of catecholamine (dopamine (DA)) and its end-products (vanillylmandelic acid (VMA) and homovanillic acid (HVA)). The Fe-SACs/Ti3C2Tx exhibits low oxidation overpotentials with high signal amplifications up to 610%, 290%, and 420%, and sensitive detection limits of 1.0, 5.0, and 10 nM for DA, VMA, and HVA, respectively. The presence of the atomic Fe elements on the Ti3C2Tx nanosheets is confirmed using high-resolution scanning transmission electron microscopy and X-ray photoelectron spectroscopy. The Fe-SACs/Ti3C2Tx sensor tracks the in situ production of DA in PC12 cells and found practically useful in analyzing human urine samples. The Fe-SACs/Ti3C2Tx stands out as a sensitive diagnostic platform for evaluating the progression of tumors and the quality of cellular DA communications.
AB - Neuroblastoma and pheochromocytoma are the most prevalent malignancies of the adrenal medulla. They are currently diagnosed by measuring urinary catecholamines using high-performance liquid chromatography-mass spectrometry, which is expensive, bulky, and tedious. Electrochemical detectors stand out as low-cost alternatives; however, further development of functional materials with adequate sensitivity is still required to attain clinically useful diagnostic devices. Here, Ti3C2Tx MXene nanosheets stabilized with iron single-atom catalysts (Fe-SACs), anchored on the surface, are synthesized and utilized as efficient electrocatalysts for the determination of catecholamine (dopamine (DA)) and its end-products (vanillylmandelic acid (VMA) and homovanillic acid (HVA)). The Fe-SACs/Ti3C2Tx exhibits low oxidation overpotentials with high signal amplifications up to 610%, 290%, and 420%, and sensitive detection limits of 1.0, 5.0, and 10 nM for DA, VMA, and HVA, respectively. The presence of the atomic Fe elements on the Ti3C2Tx nanosheets is confirmed using high-resolution scanning transmission electron microscopy and X-ray photoelectron spectroscopy. The Fe-SACs/Ti3C2Tx sensor tracks the in situ production of DA in PC12 cells and found practically useful in analyzing human urine samples. The Fe-SACs/Ti3C2Tx stands out as a sensitive diagnostic platform for evaluating the progression of tumors and the quality of cellular DA communications.
KW - 2D materials
KW - cancer
KW - diagnostic devices
KW - PC12 live cells
KW - single atom catalyst
UR - http://www.scopus.com/inward/record.url?scp=85147428847&partnerID=8YFLogxK
U2 - 10.1002/admt.202202069
DO - 10.1002/admt.202202069
M3 - Article
AN - SCOPUS:85147428847
SN - 2365-709X
VL - 8
JO - Advanced Materials Technologies
JF - Advanced Materials Technologies
IS - 6
M1 - 2202069
ER -
