TY - JOUR
T1 - Isolation, Characterization, and Medicinal Potential of Polysaccharides of Morchella esculenta
AU - Badshah, Syed Lal
AU - Riaz, Anila
AU - Muhammad, Akhtar
AU - Tel Çayan, Gülsen Tel
AU - Çayan, Fatih
AU - Emin Duru, Mehmet Emin
AU - Ahmad, Nasir
AU - Emwas, Abdul-Hamid M.
AU - Jaremko, Mariusz
N1 - KAUST Repository Item: Exported on 2021-03-10
Acknowledgements: We appreciate King Abdullah University of Science and Technology, Saudi Arabia for their support.
PY - 2021/3/8
Y1 - 2021/3/8
N2 - Mushroom polysaccharides are active medicinal compounds that possess immune-modulatory and anticancer properties. Currently, the mushroom polysaccharides krestin, lentinan, and polysaccharopeptides are used as anticancer drugs. They are an unexplored source of natural products with huge potential in both the medicinal and nutraceutical industries. The northern parts of Pakistan have a rich biodiversity of mushrooms that grow during different seasons of the year. Here we selected an edible Morchella esculenta (true morels) of the Ascomycota group for polysaccharide isolation and characterization. Polysaccharopeptides and polysaccharides from this mushroom were isolated using the green chemistry, hot water treatment method. Fourier transform infrared spectroscopy revealed the sugar nature and possible beta-glucan type structure of these polysaccharides. Antioxidant assays showed that the deproteinized polysaccharides have moderate free radical scavenging activity. These isolated polysaccharides exhibited good acetylcholinesterase (AChE) and butyryl cholinesterase (BChE) inhibition activities. Therefore, these polysaccharides may be valuable for the treatment of Alzheimer’s and Parkinson’s diseases. Further bioassays are needed to discover the true potential of M. esculenta polysaccharides for medicinal purposes.
AB - Mushroom polysaccharides are active medicinal compounds that possess immune-modulatory and anticancer properties. Currently, the mushroom polysaccharides krestin, lentinan, and polysaccharopeptides are used as anticancer drugs. They are an unexplored source of natural products with huge potential in both the medicinal and nutraceutical industries. The northern parts of Pakistan have a rich biodiversity of mushrooms that grow during different seasons of the year. Here we selected an edible Morchella esculenta (true morels) of the Ascomycota group for polysaccharide isolation and characterization. Polysaccharopeptides and polysaccharides from this mushroom were isolated using the green chemistry, hot water treatment method. Fourier transform infrared spectroscopy revealed the sugar nature and possible beta-glucan type structure of these polysaccharides. Antioxidant assays showed that the deproteinized polysaccharides have moderate free radical scavenging activity. These isolated polysaccharides exhibited good acetylcholinesterase (AChE) and butyryl cholinesterase (BChE) inhibition activities. Therefore, these polysaccharides may be valuable for the treatment of Alzheimer’s and Parkinson’s diseases. Further bioassays are needed to discover the true potential of M. esculenta polysaccharides for medicinal purposes.
UR - http://hdl.handle.net/10754/667988
UR - https://www.mdpi.com/1420-3049/26/5/1459
U2 - 10.3390/molecules26051459
DO - 10.3390/molecules26051459
M3 - Article
C2 - 33800212
SN - 1420-3049
VL - 26
SP - 1459
JO - Molecules
JF - Molecules
IS - 5
ER -