Isolation of discrete nanoparticle-DNA conjugates for plasmonic applications

Shelley A. Claridge, Huiyang W. Liang, S. Roger Basu, Jean M.J. Fréchet, A. Paul Alivisatos

Research output: Contribution to journalArticlepeer-review

156 Scopus citations


Discrete DNA gold nanoparticle conjugates with DNA lengths as short as 15 bases for both 5 and 20 nm gold particles have been purified by anion-exchange HPLC. Conjugates comprising short DNA (<40 bases) and large gold particles (≥20 nm) are difficult to purify by other means and are potential substrates for plasmon coupling experiments. Conjugate purity is demonstrated by hybridizing complementary conjugates to form discrete structures, which are visualized by TEM.

Original languageEnglish (US)
Pages (from-to)1202-1206
Number of pages5
JournalNano Letters
Issue number4
StatePublished - Apr 1 2008

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering


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