Iterative synthesis of monodisperse PEG homostars and linear heterobifunctional PEG

György Székely; Marc Schaepertoens; Piers R.J. Gaffney; Andrew G. Livingston

doi:10.1039/c3py01367g

Iterative synthesis of monodisperse PEG homostars and linear heterobifunctional PEG

György Székely, Marc Schaepertoens, Piers R.J. Gaffney^*, Andrew G. Livingston

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Highly monodisperse, heterobifunctional poly(ethylene glycol) (PEG) was prepared by iterative chain extension of a PEGylated homostar using an octagol (EG₈) building block to give MeO-EG₂₄-OH in high purity. The branched structure facilitated purification of intermediates by chromatography, and mono-functionalization of the chain termini. This approach should be extendable to other classes of oligomers.

Original language	English (US)
Pages (from-to)	694-697
Number of pages	4
Journal	POLYMER CHEMISTRY
Volume	5
Issue number	3
DOIs	https://doi.org/10.1039/c3py01367g
State	Published - Feb 7 2014
Externally published	Yes

ASJC Scopus subject areas

Bioengineering
Polymers and Plastics
Biochemistry
Organic Chemistry

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abstract = "Highly monodisperse, heterobifunctional poly(ethylene glycol) (PEG) was prepared by iterative chain extension of a PEGylated homostar using an octagol (EG8) building block to give MeO-EG24-OH in high purity. The branched structure facilitated purification of intermediates by chromatography, and mono-functionalization of the chain termini. This approach should be extendable to other classes of oligomers.",

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AU - Schaepertoens, Marc

AU - Gaffney, Piers R.J.

AU - Livingston, Andrew G.

PY - 2014/2/7

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N2 - Highly monodisperse, heterobifunctional poly(ethylene glycol) (PEG) was prepared by iterative chain extension of a PEGylated homostar using an octagol (EG8) building block to give MeO-EG24-OH in high purity. The branched structure facilitated purification of intermediates by chromatography, and mono-functionalization of the chain termini. This approach should be extendable to other classes of oligomers.

AB - Highly monodisperse, heterobifunctional poly(ethylene glycol) (PEG) was prepared by iterative chain extension of a PEGylated homostar using an octagol (EG8) building block to give MeO-EG24-OH in high purity. The branched structure facilitated purification of intermediates by chromatography, and mono-functionalization of the chain termini. This approach should be extendable to other classes of oligomers.

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Iterative synthesis of monodisperse PEG homostars and linear heterobifunctional PEG

Abstract

ASJC Scopus subject areas

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