TY - JOUR
T1 - Lactate enhances NMDA receptor responses via two distinct mechanisms
AU - Herrera-Lopez, Gabriel
AU - Lemtiri-Chlieh, Fouad
AU - Mahmood, Hanan S.
AU - Mottier, Lorene
AU - Fiumelli, Hubert
AU - Magistretti, Pierre J.
N1 - KAUST Repository Item: Exported on 2021-03-09
PY - 2019/9
Y1 - 2019/9
N2 - Lactate is known as an energy substrate for neurons. It is also emerging as a trophic signaling molecule regulating higher brain functions such as learning and memory. Lactate was shown to potentiate NMDA receptor signaling and regulate gene expression related to synaptic plasticity.
Using patch-clamp recordings in cultured cortical neurons, we found that lactate enhanced amplitude and inactivation time-constant (tau) of NMDA receptor currents (INMDA) evoked by brief applications of glutamate and glycine. The effect on the amplitude was prevented by pre-treating neurons with a MCTs blocker or by including CaMKII inhibitors in the patch pipette, whereas the effect on tau was not.
AB - Lactate is known as an energy substrate for neurons. It is also emerging as a trophic signaling molecule regulating higher brain functions such as learning and memory. Lactate was shown to potentiate NMDA receptor signaling and regulate gene expression related to synaptic plasticity.
Using patch-clamp recordings in cultured cortical neurons, we found that lactate enhanced amplitude and inactivation time-constant (tau) of NMDA receptor currents (INMDA) evoked by brief applications of glutamate and glycine. The effect on the amplitude was prevented by pre-treating neurons with a MCTs blocker or by including CaMKII inhibitors in the patch pipette, whereas the effect on tau was not.
UR - http://hdl.handle.net/10754/667965
UR - https://linkinghub.elsevier.com/retrieve/pii/S2451830119313160
U2 - 10.1016/j.ibror.2019.07.1264
DO - 10.1016/j.ibror.2019.07.1264
M3 - Article
SN - 2451-8301
VL - 6
SP - S397-S398
JO - IBRO Reports
JF - IBRO Reports
ER -