Larock indole synthesis using palladium complexes immobilized onto mesoporous silica

Nelly Batail, Anissa Bendjeriou, Laurent Djakovitch*, Véronique Dufaud

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Heterogeneous palladium catalysts were prepared by covalent immobilization of palladium (II) complexes of the general formula PdCl2L2 (L = P, CN) onto SBA-15 silica using a post-synthetic method. The state of the hybrid materials was characterized using a wide variety of molecular and solid-state techniques. In general, all the palladium modified solids exhibited highly ordered mesostructures while keeping the integrity of the parent molecular precursors. The catalytic performances of the materials were evaluated in the heteroannulation of 2-iodoaniline and 2-bromoaniline with triethyl(phenylethynyl)silane which showed high activities and selectivities with isolated yields in the range of 80-85%. Despite a decrease in the initial activity, quantitative conversion of iodoaniline to the expected product was observed over multiple recyclings, making these materials particularly efficient for such applications. The catalytic process was shown to be homogeneous in nature, the solid apparently serving as a "reservoir" for the metal between cycles.

Original languageEnglish (US)
Pages (from-to)179-187
Number of pages9
JournalApplied Catalysis A: General
Issue number1-2
StatePublished - Nov 20 2010


  • Heterogenous catalysis
  • Indoles
  • Larock synthesis
  • Palladium catalysts
  • SBA-15

ASJC Scopus subject areas

  • Catalysis
  • Process Chemistry and Technology


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