Learning a hybrid architecture for sequence regression and annotation

Yizhe Zhang, Ricardo Henao, Lawrence Carin, Jianling Zhong, Alexander J. Hartemink

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations


When learning a hidden Markov model (HMM), sequential observations can often be complemented by real-valued summary response variables generated from the path of hidden states. Such settings arise in numerous domains, including many applications in biology, like motif discovery and genome annotation. In this paper, we present a flexible framework for jointly modeling both latent sequence features and the functional mapping that relates the summary response variables to the hidden state sequence. The algorithm is compatible with a rich set of mapping functions. Results show that the availability of additional continuous response variables can simultaneously improve the annotation of the sequential observations and yield good prediction performance in both synthetic data and real-world datasets.
Original languageEnglish (US)
Title of host publication30th AAAI Conference on Artificial Intelligence, AAAI 2016
PublisherAAAI press
Number of pages7
ISBN (Print)9781577357605
StatePublished - Jan 1 2016
Externally publishedYes


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