Lhx2, a vertebrate homologue of apterous, regulates vertebrate limb outgrowth

Concepción Rodriguez-Esteban; John W.R. Schwabe; Jennifer De La Peña; Diego E. Rincon-Limas; Jorge Magallón; Juan Botas; Juan Carlos Izpisúa Belmonte

Lhx2, a vertebrate homologue of apterous, regulates vertebrate limb outgrowth

Concepción Rodriguez-Esteban, John W.R. Schwabe, Jennifer De La Peña, Diego E. Rincon-Limas, Jorge Magallón, Juan Botas, Juan Carlos Izpisúa Belmonte

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

apterous specifies dorsal cell fate and directs outgrowth of the wing during Drosophila wing development. Here we show that, in vertebrates, these functions appear to be performed by two separate proteins. Lmx-1 is necessary and sufficient to specify dorsal identity and Lhx2 regulates limb outgrowth. Our results suggest that Lhx2 is closer to apterous than Lmx-1, yet, in vertebrates, Lhx2 does not specify dorsal cell fate. This implies that in vertebrates, unlike Drosophila, limb outgrowth can be dissociated from the establishment of the dorsoventral axis.

Original language	English (US)
Pages (from-to)	3925-3934
Number of pages	10
Journal	Development
Volume	125
Issue number	20
State	Published - 1998
Externally published	Yes

Keywords

Drosophila
Lhs2
Limb outgrowth
Lmx-1
Vertebrate
apterous

ASJC Scopus subject areas

Molecular Biology
Developmental Biology

Cite this

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title = "Lhx2, a vertebrate homologue of apterous, regulates vertebrate limb outgrowth",

abstract = "apterous specifies dorsal cell fate and directs outgrowth of the wing during Drosophila wing development. Here we show that, in vertebrates, these functions appear to be performed by two separate proteins. Lmx-1 is necessary and sufficient to specify dorsal identity and Lhx2 regulates limb outgrowth. Our results suggest that Lhx2 is closer to apterous than Lmx-1, yet, in vertebrates, Lhx2 does not specify dorsal cell fate. This implies that in vertebrates, unlike Drosophila, limb outgrowth can be dissociated from the establishment of the dorsoventral axis.",

keywords = "Drosophila, Lhs2, Limb outgrowth, Lmx-1, Vertebrate, apterous",

author = "Concepci{\'o}n Rodriguez-Esteban and Schwabe, {John W.R.} and {De La Pe{\~n}a}, Jennifer and Rincon-Limas, {Diego E.} and Jorge Magall{\'o}n and Juan Botas and Belmonte, {Juan Carlos Izpis{\'u}a}",

year = "1998",

language = "English (US)",

volume = "125",

pages = "3925--3934",

journal = "Development",

issn = "0950-1991",

publisher = "Company of Biologists Ltd",

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T1 - Lhx2, a vertebrate homologue of apterous, regulates vertebrate limb outgrowth

AU - Rodriguez-Esteban, Concepción

AU - Schwabe, John W.R.

AU - De La Peña, Jennifer

AU - Rincon-Limas, Diego E.

AU - Magallón, Jorge

AU - Botas, Juan

AU - Belmonte, Juan Carlos Izpisúa

PY - 1998

Y1 - 1998

N2 - apterous specifies dorsal cell fate and directs outgrowth of the wing during Drosophila wing development. Here we show that, in vertebrates, these functions appear to be performed by two separate proteins. Lmx-1 is necessary and sufficient to specify dorsal identity and Lhx2 regulates limb outgrowth. Our results suggest that Lhx2 is closer to apterous than Lmx-1, yet, in vertebrates, Lhx2 does not specify dorsal cell fate. This implies that in vertebrates, unlike Drosophila, limb outgrowth can be dissociated from the establishment of the dorsoventral axis.

AB - apterous specifies dorsal cell fate and directs outgrowth of the wing during Drosophila wing development. Here we show that, in vertebrates, these functions appear to be performed by two separate proteins. Lmx-1 is necessary and sufficient to specify dorsal identity and Lhx2 regulates limb outgrowth. Our results suggest that Lhx2 is closer to apterous than Lmx-1, yet, in vertebrates, Lhx2 does not specify dorsal cell fate. This implies that in vertebrates, unlike Drosophila, limb outgrowth can be dissociated from the establishment of the dorsoventral axis.

KW - Drosophila

KW - Lhs2

KW - Limb outgrowth

KW - Lmx-1

KW - Vertebrate

KW - apterous

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M3 - Article

C2 - 9735354

AN - SCOPUS:0031737286

SN - 0950-1991

VL - 125

SP - 3925

EP - 3934

JO - Development

JF - Development

IS - 20

ER -

Lhx2, a vertebrate homologue of apterous, regulates vertebrate limb outgrowth

Abstract

Keywords

ASJC Scopus subject areas

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