TY - JOUR
T1 - Lifestyle-only intervention attenuates the inflammatory state associated with obesity: A randomized controlled study in adolescents
AU - Balagopal, Prabhakaran
AU - George, Donald
AU - Patton, Norman
AU - Yarandi, Hossein
AU - Roberts, William L.
AU - Bayne, Edward
AU - Gidding, Samuel
N1 - Generated from Scopus record by KAUST IRTS on 2023-09-20
PY - 2005/1/1
Y1 - 2005/1/1
N2 - Objectives: The primary goals were to understand the relationship among the inflammatory factors, C-reactive protein (CRP), interleukin-6 (IL-6), and fibrinogen, and indices of obesity in normoglycemic, insulin-resistant adolescents and to investigate the impact of a lifestyle-only intervention on these nontraditional risk factors for cardiovascular disease (CVD). Study design: Randomized controlled lifestyle-only intervention study in adolescents. Of the 21 adolescents studied, 15 obese subjects (body mass index [BMI] = 37.6 ± 3.3 kg/m2) were randomized to either a lifestyle intervention program or usual care. The lean controls were studied only at baseline. Analysis of variance (ANOVA) for repeated measures was used to study intervention effect and t test, one-way ANOVA, and discriminant function analysis for baseline comparisons. Results: The intervention group maintained weight, whereas the control group gained weight (P =. 02). A redistribution of body composition and a decrease in insulin resistance were observed. Elevated circulating concentrations of CRP, fibrinogen, and IL-6 were significantly reduced (all P ≤.02) in response to intervention, but not in controls. Conclusions: Modest lifestyle-only change in previously sedentary obese adolescents redistributes the parameters of body composition in the absence of weight loss and reverses, at least in part, the inflammatory state in association with an improvement of insulin resistance. Copyright © 2005 Elsevier Inc.All rights reserved.
AB - Objectives: The primary goals were to understand the relationship among the inflammatory factors, C-reactive protein (CRP), interleukin-6 (IL-6), and fibrinogen, and indices of obesity in normoglycemic, insulin-resistant adolescents and to investigate the impact of a lifestyle-only intervention on these nontraditional risk factors for cardiovascular disease (CVD). Study design: Randomized controlled lifestyle-only intervention study in adolescents. Of the 21 adolescents studied, 15 obese subjects (body mass index [BMI] = 37.6 ± 3.3 kg/m2) were randomized to either a lifestyle intervention program or usual care. The lean controls were studied only at baseline. Analysis of variance (ANOVA) for repeated measures was used to study intervention effect and t test, one-way ANOVA, and discriminant function analysis for baseline comparisons. Results: The intervention group maintained weight, whereas the control group gained weight (P =. 02). A redistribution of body composition and a decrease in insulin resistance were observed. Elevated circulating concentrations of CRP, fibrinogen, and IL-6 were significantly reduced (all P ≤.02) in response to intervention, but not in controls. Conclusions: Modest lifestyle-only change in previously sedentary obese adolescents redistributes the parameters of body composition in the absence of weight loss and reverses, at least in part, the inflammatory state in association with an improvement of insulin resistance. Copyright © 2005 Elsevier Inc.All rights reserved.
UR - https://linkinghub.elsevier.com/retrieve/pii/S0022347604011205
UR - http://www.scopus.com/inward/record.url?scp=14844320865&partnerID=8YFLogxK
U2 - 10.1016/j.jpeds.2004.11.033
DO - 10.1016/j.jpeds.2004.11.033
M3 - Article
SN - 0022-3476
VL - 146
SP - 342
EP - 348
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 3
ER -
