TY - CHAP
T1 - Lipids, docosahexaenoic acid (DHA), and traumatic brain injury
AU - Darwish, Batoul
AU - El-Mallah, Carla
AU - Kobeissy, Firas
AU - Abou-Kheir, Wassim
AU - Chamaa, Farah
N1 - KAUST Repository Item: Exported on 2023-09-04
PY - 2023/6/16
Y1 - 2023/6/16
N2 - Traumatic brain injury (TBI) is one of the leading causes of death or disability in incidents of trauma. It continues to be clinically challenging to find absolute treatments that can manage and control all aspects of secondary injury post-TBI. While some fat diets, like high-fat diet (HFD), are bad, emerging evidence suggests that early treatment with omega-3 polyunsaturated fatty acids (PUFAs), given at optimal doses, offers therapeutic potential in improving TBI outcomes. Omega-3 PUFA family is the main structural components of cell membranes, and namely, the docosahexaenoic acid (DHA) is mostly concentrated in the brain. This chapter will shed light on fat diets, and on how omega-3 supplementation offers a safe and promising therapeutic approach for TBI among other neurological disorders. More specifically, it will highlight the effects of DHA of the omega-3 PUFA family, on neuroinflammation and neuroprotection in the context of TBI.
AB - Traumatic brain injury (TBI) is one of the leading causes of death or disability in incidents of trauma. It continues to be clinically challenging to find absolute treatments that can manage and control all aspects of secondary injury post-TBI. While some fat diets, like high-fat diet (HFD), are bad, emerging evidence suggests that early treatment with omega-3 polyunsaturated fatty acids (PUFAs), given at optimal doses, offers therapeutic potential in improving TBI outcomes. Omega-3 PUFA family is the main structural components of cell membranes, and namely, the docosahexaenoic acid (DHA) is mostly concentrated in the brain. This chapter will shed light on fat diets, and on how omega-3 supplementation offers a safe and promising therapeutic approach for TBI among other neurological disorders. More specifically, it will highlight the effects of DHA of the omega-3 PUFA family, on neuroinflammation and neuroprotection in the context of TBI.
UR - http://hdl.handle.net/10754/694006
UR - https://linkinghub.elsevier.com/retrieve/pii/B9780323898348000283
UR - http://www.scopus.com/inward/record.url?scp=85166138243&partnerID=8YFLogxK
U2 - 10.1016/B978-0-323-89834-8.00028-3
DO - 10.1016/B978-0-323-89834-8.00028-3
M3 - Chapter
SN - 9780323898348
SP - 239
EP - 255
BT - Diet and Nutrition in Neurological Disorders
PB - Elsevier
ER -