Lipids, docosahexaenoic acid (DHA), and traumatic brain injury

Batoul Darwish, Carla El-Mallah, Firas Kobeissy, Wassim Abou-Kheir, Farah Chamaa

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Traumatic brain injury (TBI) is one of the leading causes of death or disability in incidents of trauma. It continues to be clinically challenging to find absolute treatments that can manage and control all aspects of secondary injury post-TBI. While some fat diets, like high-fat diet (HFD), are bad, emerging evidence suggests that early treatment with omega-3 polyunsaturated fatty acids (PUFAs), given at optimal doses, offers therapeutic potential in improving TBI outcomes. Omega-3 PUFA family is the main structural components of cell membranes, and namely, the docosahexaenoic acid (DHA) is mostly concentrated in the brain. This chapter will shed light on fat diets, and on how omega-3 supplementation offers a safe and promising therapeutic approach for TBI among other neurological disorders. More specifically, it will highlight the effects of DHA of the omega-3 PUFA family, on neuroinflammation and neuroprotection in the context of TBI.
Original languageEnglish (US)
Title of host publicationDiet and Nutrition in Neurological Disorders
PublisherElsevier
Pages239-255
Number of pages17
ISBN (Print)9780323898348
DOIs
StatePublished - Jun 16 2023

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