Magnetic nanocarriers with tunable pH dependence for controlled loading and release of cationic and anionic payloads

Nadja C. Bigall; Alberto Curcio; Manuel Pernia Leal; Andrea Falqui; Domenico Palumberi; Riccardo Di Corato; Ennio Albanesi; Roberto Cingolani; Teresa Pellegrino

doi:10.1002/adma.201103505

Magnetic nanocarriers with tunable pH dependence for controlled loading and release of cationic and anionic payloads

Nadja C. Bigall, Alberto Curcio, Manuel Pernia Leal, Andrea Falqui, Domenico Palumberi, Riccardo Di Corato, Ennio Albanesi, Roberto Cingolani, Teresa Pellegrino^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Superparamagnetic nanocarriers with tunable pH dependence of the surface charge are designed by a simple co-precipitation method. By exploiting electrostatic interactions, cationic or anionic payloads can be adsorbed and desorbed depending on the pH. On three different resulting nanocarrier systems, experiments of loading and release of gold nanoparticles as well as effective siRNA loading and in vitro delivery on human cells are performed.

Original language	English (US)
Pages (from-to)	5645-5650
Number of pages	6
Journal	Advanced Materials
Volume	23
Issue number	47
DOIs	https://doi.org/10.1002/adma.201103505
State	Published - Dec 15 2011
Externally published	Yes

Keywords

gold nanoparticles
magnetic nanobeads
pH-responsive materials
siRNA delivery
superparamagnetic nanocarriers

ASJC Scopus subject areas

General Materials Science
Mechanics of Materials
Mechanical Engineering

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10.1002/adma.201103505

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title = "Magnetic nanocarriers with tunable pH dependence for controlled loading and release of cationic and anionic payloads",

abstract = "Superparamagnetic nanocarriers with tunable pH dependence of the surface charge are designed by a simple co-precipitation method. By exploiting electrostatic interactions, cationic or anionic payloads can be adsorbed and desorbed depending on the pH. On three different resulting nanocarrier systems, experiments of loading and release of gold nanoparticles as well as effective siRNA loading and in vitro delivery on human cells are performed.",

keywords = "gold nanoparticles, magnetic nanobeads, pH-responsive materials, siRNA delivery, superparamagnetic nanocarriers",

author = "Bigall, {Nadja C.} and Alberto Curcio and Leal, {Manuel Pernia} and Andrea Falqui and Domenico Palumberi and {Di Corato}, Riccardo and Ennio Albanesi and Roberto Cingolani and Teresa Pellegrino",

year = "2011",

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doi = "10.1002/adma.201103505",

language = "English (US)",

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journal = "Advanced Materials",

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T1 - Magnetic nanocarriers with tunable pH dependence for controlled loading and release of cationic and anionic payloads

AU - Bigall, Nadja C.

AU - Curcio, Alberto

AU - Leal, Manuel Pernia

AU - Falqui, Andrea

AU - Palumberi, Domenico

AU - Di Corato, Riccardo

AU - Albanesi, Ennio

AU - Cingolani, Roberto

AU - Pellegrino, Teresa

PY - 2011/12/15

Y1 - 2011/12/15

N2 - Superparamagnetic nanocarriers with tunable pH dependence of the surface charge are designed by a simple co-precipitation method. By exploiting electrostatic interactions, cationic or anionic payloads can be adsorbed and desorbed depending on the pH. On three different resulting nanocarrier systems, experiments of loading and release of gold nanoparticles as well as effective siRNA loading and in vitro delivery on human cells are performed.

AB - Superparamagnetic nanocarriers with tunable pH dependence of the surface charge are designed by a simple co-precipitation method. By exploiting electrostatic interactions, cationic or anionic payloads can be adsorbed and desorbed depending on the pH. On three different resulting nanocarrier systems, experiments of loading and release of gold nanoparticles as well as effective siRNA loading and in vitro delivery on human cells are performed.

KW - gold nanoparticles

KW - magnetic nanobeads

KW - pH-responsive materials

KW - siRNA delivery

KW - superparamagnetic nanocarriers

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U2 - 10.1002/adma.201103505

DO - 10.1002/adma.201103505

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VL - 23

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JO - Advanced Materials

JF - Advanced Materials

IS - 47

ER -

Magnetic nanocarriers with tunable pH dependence for controlled loading and release of cationic and anionic payloads

Abstract

Keywords

ASJC Scopus subject areas

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