Magnetic pH-responsive nanogels as multifunctional delivery tools for small interfering RNA (siRNA) molecules and iron oxide nanoparticles (IONPs)

Alberto Curcio; Roberto Marotta; Domenico Palumberi; Andrea Falqui; Teresa Pellegrino

doi:10.1039/c2cc17223b

Magnetic pH-responsive nanogels as multifunctional delivery tools for small interfering RNA (siRNA) molecules and iron oxide nanoparticles (IONPs)

Alberto Curcio, Roberto Marotta, Domenico Palumberi, Andrea Falqui, Teresa Pellegrino^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

We here exploit pH-responsive nanogels as carriers to deliver functional anti-GFP siRNA and superparamagnetic IONPs to HeLa–GFP cells. The siRNA release via pH-mediated endosomal escape is shown. The IONPs act first as magnetofection agents to boost cellular uptake and then as probes to track the release mechanism by electron microscopy.

Original language	English (US)
Pages (from-to)	2400-2402
Number of pages	3
Journal	CHEMICAL COMMUNICATIONS
Volume	48
Issue number	18
DOIs	https://doi.org/10.1039/c2cc17223b
State	Published - Feb 1 2012
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c2cc17223b

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title = "Magnetic pH-responsive nanogels as multifunctional delivery tools for small interfering RNA (siRNA) molecules and iron oxide nanoparticles (IONPs)",

abstract = "We here exploit pH-responsive nanogels as carriers to deliver functional anti-GFP siRNA and superparamagnetic IONPs to HeLa–GFP cells. The siRNA release via pH-mediated endosomal escape is shown. The IONPs act first as magnetofection agents to boost cellular uptake and then as probes to track the release mechanism by electron microscopy.",

author = "Alberto Curcio and Roberto Marotta and Domenico Palumberi and Andrea Falqui and Teresa Pellegrino",

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AU - Curcio, Alberto

AU - Marotta, Roberto

AU - Palumberi, Domenico

AU - Falqui, Andrea

AU - Pellegrino, Teresa

PY - 2012/2/1

Y1 - 2012/2/1

N2 - We here exploit pH-responsive nanogels as carriers to deliver functional anti-GFP siRNA and superparamagnetic IONPs to HeLa–GFP cells. The siRNA release via pH-mediated endosomal escape is shown. The IONPs act first as magnetofection agents to boost cellular uptake and then as probes to track the release mechanism by electron microscopy.

AB - We here exploit pH-responsive nanogels as carriers to deliver functional anti-GFP siRNA and superparamagnetic IONPs to HeLa–GFP cells. The siRNA release via pH-mediated endosomal escape is shown. The IONPs act first as magnetofection agents to boost cellular uptake and then as probes to track the release mechanism by electron microscopy.

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Magnetic pH-responsive nanogels as multifunctional delivery tools for small interfering RNA (siRNA) molecules and iron oxide nanoparticles (IONPs)

Abstract

ASJC Scopus subject areas

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