Abstract
We here exploit pH-responsive nanogels as carriers to deliver functional anti-GFP siRNA and superparamagnetic IONPs to HeLa–GFP cells. The siRNA release via pH-mediated endosomal escape is shown. The IONPs act first as magnetofection agents to boost cellular uptake and then as probes to track the release mechanism by electron microscopy.
Original language | English (US) |
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Pages (from-to) | 2400-2402 |
Number of pages | 3 |
Journal | CHEMICAL COMMUNICATIONS |
Volume | 48 |
Issue number | 18 |
DOIs | |
State | Published - Feb 1 2012 |
Externally published | Yes |
ASJC Scopus subject areas
- Catalysis
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- General Chemistry
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry