Magnetic targeting core/shell Fe 3 O 4 /Au nanoparticles for magnetic resonance/photoacoustic dual-modal imaging

Ning Kang; Dan Xu; Yu Han; Xiaolin Lv; Zhiwei Chen; Tiantian Zhou; Lei Ren; Xi Zhou

doi:10.1016/j.msec.2019.01.013

Magnetic targeting core/shell Fe 3 O 4 /Au nanoparticles for magnetic resonance/photoacoustic dual-modal imaging

Ning Kang, Dan Xu, Yu Han, Xiaolin Lv, Zhiwei Chen, Tiantian Zhou, Lei Ren, Xi Zhou

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

This study reports magnetic targeting guided magnetic (MR)/photoacoustic (PA) dual-modal imaging by core/shell Fe 3 O 4 /Au nanoparticles. In this work, MR imaging provides time-dependent tumor location, and PA imaging reveals high resolution vasculatures inside the tumor. It is noted that the synthesized Fe 3 O 4 /Au nanoparticles exhibited higher r 2 value up to 329 mM −1 s −1 than previously reported T 2 contrast agents. Furthermore, the Fe 3 O 4 /Au NPs are applied as a promising candidate for in vivo MR/PA imaging of tumors by intravenously injection into LNCaP tumor-beared mice. The MR/PA imaging results show a significantly enhanced MR/PA images in the tumor site. The prepared core/shell Fe 3 O 4 /Au nanoparticles will be widely applicable in multi-modal imaging.

Original language	English (US)
Pages (from-to)	545-549
Number of pages	5
Journal	Materials Science and Engineering C
Volume	98
DOIs	https://doi.org/10.1016/j.msec.2019.01.013
State	Published - May 1 2019
Externally published	Yes

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title = "Magnetic targeting core/shell Fe 3 O 4 /Au nanoparticles for magnetic resonance/photoacoustic dual-modal imaging",

abstract = "This study reports magnetic targeting guided magnetic (MR)/photoacoustic (PA) dual-modal imaging by core/shell Fe 3 O 4 /Au nanoparticles. In this work, MR imaging provides time-dependent tumor location, and PA imaging reveals high resolution vasculatures inside the tumor. It is noted that the synthesized Fe 3 O 4 /Au nanoparticles exhibited higher r 2 value up to 329 mM −1 s −1 than previously reported T 2 contrast agents. Furthermore, the Fe 3 O 4 /Au NPs are applied as a promising candidate for in vivo MR/PA imaging of tumors by intravenously injection into LNCaP tumor-beared mice. The MR/PA imaging results show a significantly enhanced MR/PA images in the tumor site. The prepared core/shell Fe 3 O 4 /Au nanoparticles will be widely applicable in multi-modal imaging.",

author = "Ning Kang and Dan Xu and Yu Han and Xiaolin Lv and Zhiwei Chen and Tiantian Zhou and Lei Ren and Xi Zhou",

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doi = "10.1016/j.msec.2019.01.013",

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T1 - Magnetic targeting core/shell Fe 3 O 4 /Au nanoparticles for magnetic resonance/photoacoustic dual-modal imaging

AU - Kang, Ning

AU - Xu, Dan

AU - Han, Yu

AU - Lv, Xiaolin

AU - Chen, Zhiwei

AU - Zhou, Tiantian

AU - Ren, Lei

AU - Zhou, Xi

N1 - Generated from Scopus record by KAUST IRTS on 2023-09-21

PY - 2019/5/1

Y1 - 2019/5/1

N2 - This study reports magnetic targeting guided magnetic (MR)/photoacoustic (PA) dual-modal imaging by core/shell Fe 3 O 4 /Au nanoparticles. In this work, MR imaging provides time-dependent tumor location, and PA imaging reveals high resolution vasculatures inside the tumor. It is noted that the synthesized Fe 3 O 4 /Au nanoparticles exhibited higher r 2 value up to 329 mM −1 s −1 than previously reported T 2 contrast agents. Furthermore, the Fe 3 O 4 /Au NPs are applied as a promising candidate for in vivo MR/PA imaging of tumors by intravenously injection into LNCaP tumor-beared mice. The MR/PA imaging results show a significantly enhanced MR/PA images in the tumor site. The prepared core/shell Fe 3 O 4 /Au nanoparticles will be widely applicable in multi-modal imaging.

AB - This study reports magnetic targeting guided magnetic (MR)/photoacoustic (PA) dual-modal imaging by core/shell Fe 3 O 4 /Au nanoparticles. In this work, MR imaging provides time-dependent tumor location, and PA imaging reveals high resolution vasculatures inside the tumor. It is noted that the synthesized Fe 3 O 4 /Au nanoparticles exhibited higher r 2 value up to 329 mM −1 s −1 than previously reported T 2 contrast agents. Furthermore, the Fe 3 O 4 /Au NPs are applied as a promising candidate for in vivo MR/PA imaging of tumors by intravenously injection into LNCaP tumor-beared mice. The MR/PA imaging results show a significantly enhanced MR/PA images in the tumor site. The prepared core/shell Fe 3 O 4 /Au nanoparticles will be widely applicable in multi-modal imaging.

UR - https://linkinghub.elsevier.com/retrieve/pii/S0928493118306842

UR - http://www.scopus.com/inward/record.url?scp=85059664550&partnerID=8YFLogxK

U2 - 10.1016/j.msec.2019.01.013

DO - 10.1016/j.msec.2019.01.013

M3 - Article

SN - 1873-0191

VL - 98

SP - 545

EP - 549

JO - Materials Science and Engineering C

JF - Materials Science and Engineering C

ER -

Magnetic targeting core/shell Fe 3 O 4 /Au nanoparticles for magnetic resonance/photoacoustic dual-modal imaging

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