Manganese Catalyzed Regioselective C–H Alkylation: Experiment and Computation

Chengming Wang, Bholanath Maity, Luigi Cavallo, Magnus Rueping

Research output: Contribution to journalArticlepeer-review

54 Scopus citations


A new efficient manganese-catalyzed selective C2-alkylation of indoles via carbenoid insertion has been achieved. The newly developed C-H functionalization protocol provides access to diverse products and shows good functional group tolerance. Mechanistic and computational studies support the formation of a Mn(CO)3 acetate complex as the catalytically active species.
Original languageEnglish (US)
Pages (from-to)3105-3108
Number of pages4
JournalOrganic Letters
Issue number10
StatePublished - May 8 2018


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