Manganese doped-iron oxide nanoparticle clusters and their potential as agents for magnetic resonance imaging and hyperthermia

Maria F. Casula; Erika Conca; Ioanna Bakaimi; Ayyappan Sathya; Maria Elena Materia; Alberto Casu; Andrea Falqui; Elisa Sogne; Teresa Pellegrino; Antonios G. Kanaras

doi:10.1039/c6cp02094a

Manganese doped-iron oxide nanoparticle clusters and their potential as agents for magnetic resonance imaging and hyperthermia

Maria F. Casula, Erika Conca, Ioanna Bakaimi, Ayyappan Sathya, Maria Elena Materia, Alberto Casu, Andrea Falqui, Elisa Sogne, Teresa Pellegrino, Antonios G. Kanaras

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67 Scopus citations

Abstract

A simple, one pot method to synthesize water-dispersible Mn doped iron oxide colloidal clusters constructed of nanoparticles arranged into secondary flower-like structures was developed. This method allows the successful incorporation and homogeneous distribution of Mn within the nanoparticle iron oxide clusters. The formed clusters retain the desired morphological and structural features observed for pure iron oxide clusters, but possess intrinsic magnetic properties that arise from Mn doping. They show distinct performance as imaging contrast agents and excellent characteristics as heating mediators in magnetic fluid hyperthermia. It is expected that the outcomes of this study will open up new avenues for the exploitation of doped magnetic nanoparticle assemblies in biomedicine. © the Owner Societies 2016.

Original language	English (US)
Pages (from-to)	16848-16855
Number of pages	8
Journal	Phys. Chem. Chem. Phys.
Volume	18
Issue number	25
DOIs	https://doi.org/10.1039/c6cp02094a
State	Published - 2016

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@article{405f7975e26045989438aa173ac659b8,

title = "Manganese doped-iron oxide nanoparticle clusters and their potential as agents for magnetic resonance imaging and hyperthermia",

abstract = "A simple, one pot method to synthesize water-dispersible Mn doped iron oxide colloidal clusters constructed of nanoparticles arranged into secondary flower-like structures was developed. This method allows the successful incorporation and homogeneous distribution of Mn within the nanoparticle iron oxide clusters. The formed clusters retain the desired morphological and structural features observed for pure iron oxide clusters, but possess intrinsic magnetic properties that arise from Mn doping. They show distinct performance as imaging contrast agents and excellent characteristics as heating mediators in magnetic fluid hyperthermia. It is expected that the outcomes of this study will open up new avenues for the exploitation of doped magnetic nanoparticle assemblies in biomedicine. {\textcopyright} the Owner Societies 2016.",

author = "Casula, {Maria F.} and Erika Conca and Ioanna Bakaimi and Ayyappan Sathya and Materia, {Maria Elena} and Alberto Casu and Andrea Falqui and Elisa Sogne and Teresa Pellegrino and Kanaras, {Antonios G.}",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: The University of Southampton is gratefully acknowledged for partial financial support of this project. A. G. K. would like to thank the EU COST action MP1202 for networking opportunities. M. F. C. thanks the Fondazione Banco di Sardegna. T. P. acknowledges funding form the Italian AIRC project (contract no. 14527) and the Cariplo foundation (contract no. 20130865).",

year = "2016",

doi = "10.1039/c6cp02094a",

language = "English (US)",

volume = "18",

pages = "16848--16855",

journal = "Phys. Chem. Chem. Phys.",

issn = "1463-9076",

publisher = "Royal Society of Chemistry",

number = "25",

}

TY - JOUR

T1 - Manganese doped-iron oxide nanoparticle clusters and their potential as agents for magnetic resonance imaging and hyperthermia

AU - Casula, Maria F.

AU - Conca, Erika

AU - Bakaimi, Ioanna

AU - Sathya, Ayyappan

AU - Materia, Maria Elena

AU - Casu, Alberto

AU - Falqui, Andrea

AU - Sogne, Elisa

AU - Pellegrino, Teresa

AU - Kanaras, Antonios G.

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: The University of Southampton is gratefully acknowledged for partial financial support of this project. A. G. K. would like to thank the EU COST action MP1202 for networking opportunities. M. F. C. thanks the Fondazione Banco di Sardegna. T. P. acknowledges funding form the Italian AIRC project (contract no. 14527) and the Cariplo foundation (contract no. 20130865).

PY - 2016

Y1 - 2016

N2 - A simple, one pot method to synthesize water-dispersible Mn doped iron oxide colloidal clusters constructed of nanoparticles arranged into secondary flower-like structures was developed. This method allows the successful incorporation and homogeneous distribution of Mn within the nanoparticle iron oxide clusters. The formed clusters retain the desired morphological and structural features observed for pure iron oxide clusters, but possess intrinsic magnetic properties that arise from Mn doping. They show distinct performance as imaging contrast agents and excellent characteristics as heating mediators in magnetic fluid hyperthermia. It is expected that the outcomes of this study will open up new avenues for the exploitation of doped magnetic nanoparticle assemblies in biomedicine. © the Owner Societies 2016.

AB - A simple, one pot method to synthesize water-dispersible Mn doped iron oxide colloidal clusters constructed of nanoparticles arranged into secondary flower-like structures was developed. This method allows the successful incorporation and homogeneous distribution of Mn within the nanoparticle iron oxide clusters. The formed clusters retain the desired morphological and structural features observed for pure iron oxide clusters, but possess intrinsic magnetic properties that arise from Mn doping. They show distinct performance as imaging contrast agents and excellent characteristics as heating mediators in magnetic fluid hyperthermia. It is expected that the outcomes of this study will open up new avenues for the exploitation of doped magnetic nanoparticle assemblies in biomedicine. © the Owner Societies 2016.

UR - http://hdl.handle.net/10754/621446

UR - http://xlink.rsc.org/?DOI=C6CP02094A

UR - http://www.scopus.com/inward/record.url?scp=84976324059&partnerID=8YFLogxK

U2 - 10.1039/c6cp02094a

DO - 10.1039/c6cp02094a

M3 - Article

C2 - 27282828

SN - 1463-9076

VL - 18

SP - 16848

EP - 16855

JO - Phys. Chem. Chem. Phys.

JF - Phys. Chem. Chem. Phys.

IS - 25

ER -

Manganese doped-iron oxide nanoparticle clusters and their potential as agents for magnetic resonance imaging and hyperthermia

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