McClintock's challenge in the 21st century

Nina V. Fedoroff

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


In 1950, Barbara McClintock published a Classic PNAS article, "The origin and behavior of mutable loci in maize," which summarized the evidence leading to her discovery of transposition. The article described a number of genome alterations revealed through her studies of the Dissociation locus, the first mobile genetic element she identified. McClintock described the suite of nuclear events, including transposon activation and various chromosome aberrations and rearrangements, that unfolded in the wake of genetic crosses that brought together two broken chromosomes 9. McClintock left future generations with the challenge of understanding how genomes respond to genetic and environmental stresses by mounting adaptive responses that frequently include genome restructuring.
Original languageEnglish (US)
Pages (from-to)20200-20203
Number of pages4
JournalProceedings of the National Academy of Sciences
Issue number50
StatePublished - Nov 13 2012

ASJC Scopus subject areas

  • General


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