Medicinal chemistry perspective of pyrido[2,3-d]pyrimidines as anticancer agents

Adarsh Kumar, Kuber Kumar Bhagat, Ankit Kumar Singh, Harshwardhan Singh, Tanuja Angre, Amita Verma, Habibullah Khalilullah, Mariusz Jaremko, Abdul-Hamid M. Emwas, Pradeep Kumar

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Cancer is a major cause of deaths across the globe due to chemoresistance and lack of selective chemotherapy. Pyrido[2,3-d]pyrimidine is an emerging scaffold in medicinal chemistry having a broad spectrum of activities, including antitumor, antibacterial, CNS depressive, anticonvulsant, and antipyretic activities. In this study, we have covered different cancer targets, including tyrosine kinase, extracellular regulated protein kinases – ABL kinase, phosphatidylinositol-3 kinase, mammalian target of rapamycin, p38 mitogen-activated protein kinases, BCR-ABL, dihydrofolate reductase, cyclin-dependent kinase, phosphodiesterase, KRAS and fibroblast growth factor receptors, their signaling pathways, mechanism of action and structure–activity relationship of pyrido[2,3-d]pyrimidine derivatives as inhibitors of the above-mentioned targets. This review will represent the complete medicinal and pharmacological profile of pyrido[2,3-d]pyrimidines as anticancer agents, and will help scientists to design new selective, effective and safe anticancer agents.
Original languageEnglish (US)
Pages (from-to)6872-6908
Number of pages37
JournalRSC Advances
Volume13
Issue number10
DOIs
StatePublished - Feb 28 2023

ASJC Scopus subject areas

  • General Chemical Engineering
  • General Chemistry

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