Metabolic exit from naive pluripotency

Jun Wu; Juan Carlos Izpisua Belmonte

doi:10.1038/ncb3269

Metabolic exit from naive pluripotency

Jun Wu^*, Juan Carlos Izpisua Belmonte

^*Corresponding author for this work

Biological, Environmental Sciences and Engineering

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Spatiotemporally distinct pluripotent states captured in vitro provide an accessible way of modelling early human development. An intricate interplay between the metabolome and histone modifications is now shown to drive the metabolic switch from human naive to primed pluripotency, one of the earliest steps of embryogenesis.

Original language	English (US)
Pages (from-to)	1519-1521
Number of pages	3
Journal	Nature Cell Biology
Volume	17
Issue number	12
DOIs	https://doi.org/10.1038/ncb3269
State	Published - Nov 27 2015

ASJC Scopus subject areas

Cell Biology

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title = "Metabolic exit from naive pluripotency",

abstract = "Spatiotemporally distinct pluripotent states captured in vitro provide an accessible way of modelling early human development. An intricate interplay between the metabolome and histone modifications is now shown to drive the metabolic switch from human naive to primed pluripotency, one of the earliest steps of embryogenesis.",

author = "Jun Wu and Belmonte, {Juan Carlos Izpisua}",

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AB - Spatiotemporally distinct pluripotent states captured in vitro provide an accessible way of modelling early human development. An intricate interplay between the metabolome and histone modifications is now shown to drive the metabolic switch from human naive to primed pluripotency, one of the earliest steps of embryogenesis.

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JO - Nature Cell Biology

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Metabolic exit from naive pluripotency

Abstract

ASJC Scopus subject areas

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