TY - JOUR
T1 - Metal Complex Formation and Anticancer Activity of Cu(I) and Cu(II) Complexes with Metformin
AU - Abdelrahman, Sherin
AU - Alghrably, Mawadda
AU - Campagna, Marcello
AU - Hauser, Charlotte Armgard Emma
AU - Jaremko, Mariusz
AU - Lachowicz, Joanna Izabela
N1 - KAUST Repository Item: Exported on 2021-08-10
Acknowledgements: We would like to thank Farid Ahmad from the center of excellence in genomic medicine research (CEGMR) for providing both the K562 and K562/Adr200 cell lines.
PY - 2021/8/5
Y1 - 2021/8/5
N2 - Metformin has been used for decades in millions of type 2 diabetes mellitus patients. In this time, correlations between metformin use and the occurrence of other disorders have been noted, as well as unpredictable metformin side effects. Diabetes is a significant cancer risk factor, but unexpectedly, metformin-treated diabetic patients have lower cancer incidence. Here, we show that metformin forms stable complexes with copper (II) ions. Both copper(I)/metformin and copper(II)/metformin complexes form adducts with glutathione, the main intracellular antioxidative peptide, found at high levels in cancer cells. Metformin reduces cell number and viability in SW1222 and K562 cells, as well as in K562-200 multidrug-resistant cells. Notably, the antiproliferative effect of metformin is enhanced in the presence of copper ions.
AB - Metformin has been used for decades in millions of type 2 diabetes mellitus patients. In this time, correlations between metformin use and the occurrence of other disorders have been noted, as well as unpredictable metformin side effects. Diabetes is a significant cancer risk factor, but unexpectedly, metformin-treated diabetic patients have lower cancer incidence. Here, we show that metformin forms stable complexes with copper (II) ions. Both copper(I)/metformin and copper(II)/metformin complexes form adducts with glutathione, the main intracellular antioxidative peptide, found at high levels in cancer cells. Metformin reduces cell number and viability in SW1222 and K562 cells, as well as in K562-200 multidrug-resistant cells. Notably, the antiproliferative effect of metformin is enhanced in the presence of copper ions.
UR - http://hdl.handle.net/10754/670468
UR - https://www.mdpi.com/1420-3049/26/16/4730
U2 - 10.3390/molecules26164730
DO - 10.3390/molecules26164730
M3 - Article
C2 - 34443319
SN - 1420-3049
VL - 26
SP - 4730
JO - Molecules
JF - Molecules
IS - 16
ER -