Abstract
A highly regioselective and efficient metal-free hydration of aromatic haloalkynes to alpha-halomethyl ketones using cheap tetrafluoroboric acid as catalyst is described. The protocol is conducted under convenient conditions and affords products in good to excellent yields, with broad substrate scope, including a variety of aromatic alkynyl chlorides, alkynyl bromides, and alkynyl iodides. (C) 2016 Elsevier Ltd. All rights reserved.
Original language | English (US) |
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Pages (from-to) | 4983-4986 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 57 |
Issue number | 45 |
DOIs | |
State | Published - Oct 1 2016 |