TY - JOUR
T1 - Metal-free hydration of aromatic haloalkynes to α-halomethyl ketones
AU - Ye, Min
AU - Wen, Yuelu
AU - Li, Huifang
AU - Fu, Yejuan
AU - Wang, Qinghao
N1 - KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: The authors thank the NSFC (21202023) and the NSF of Jiangxi Provincial Education Department (GJJ151005 and GJJ14656) for financial support.
PY - 2016/10/1
Y1 - 2016/10/1
N2 - A highly regioselective and efficient metal-free hydration of aromatic haloalkynes to alpha-halomethyl ketones using cheap tetrafluoroboric acid as catalyst is described. The protocol is conducted under convenient conditions and affords products in good to excellent yields, with broad substrate scope, including a variety of aromatic alkynyl chlorides, alkynyl bromides, and alkynyl iodides. (C) 2016 Elsevier Ltd. All rights reserved.
AB - A highly regioselective and efficient metal-free hydration of aromatic haloalkynes to alpha-halomethyl ketones using cheap tetrafluoroboric acid as catalyst is described. The protocol is conducted under convenient conditions and affords products in good to excellent yields, with broad substrate scope, including a variety of aromatic alkynyl chlorides, alkynyl bromides, and alkynyl iodides. (C) 2016 Elsevier Ltd. All rights reserved.
UR - http://hdl.handle.net/10754/622311
UR - http://www.sciencedirect.com/science/article/pii/S0040403916312722
UR - http://www.scopus.com/inward/record.url?scp=84991409756&partnerID=8YFLogxK
U2 - 10.1016/j.tetlet.2016.09.088
DO - 10.1016/j.tetlet.2016.09.088
M3 - Article
SN - 0040-4039
VL - 57
SP - 4983
EP - 4986
JO - Tetrahedron Letters
JF - Tetrahedron Letters
IS - 45
ER -