Metal-free hydration of aromatic haloalkynes to α-halomethyl ketones

Min Ye, Yuelu Wen, Huifang Li, Yejuan Fu, Qinghao Wang

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


A highly regioselective and efficient metal-free hydration of aromatic haloalkynes to alpha-halomethyl ketones using cheap tetrafluoroboric acid as catalyst is described. The protocol is conducted under convenient conditions and affords products in good to excellent yields, with broad substrate scope, including a variety of aromatic alkynyl chlorides, alkynyl bromides, and alkynyl iodides. (C) 2016 Elsevier Ltd. All rights reserved.
Original languageEnglish (US)
Pages (from-to)4983-4986
Number of pages4
JournalTetrahedron Letters
Issue number45
StatePublished - Oct 1 2016


Dive into the research topics of 'Metal-free hydration of aromatic haloalkynes to α-halomethyl ketones'. Together they form a unique fingerprint.

Cite this