Method specific second-trimester reference intervals for thyroid-stimulating hormone and free thyroxine

Rechelle Silvio; Karly J. Swapp; Sonia L. La'ulu; Kara Hansen-Suchy; William L. Roberts

doi:10.1016/j.clinbiochem.2008.12.004

Method specific second-trimester reference intervals for thyroid-stimulating hormone and free thyroxine

Rechelle Silvio, Karly J. Swapp, Sonia L. La'ulu, Kara Hansen-Suchy, William L. Roberts

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Objective: To determine second trimester reference intervals for TSH and FT4. Design: Samples from 3102 subjects were tested for TPO and Tg antibodies. Methods: Elecsys E170 reference intervals for TSH and FT4 were determined using antibody-negative samples. Results: Second trimester reference intervals for TSH and FT4 were 0.18-4.07 mIU/L and 9.5-15.8 pmol/L, respectively. The Elecsys E170 TSH results were positively biased compared to ARCHITECT i2000SR results for these same samples. Conclusions: Method-specific reference intervals are required for TSH and FT4. © 2008 The Canadian Society of Clinical Chemists.

Original language	English (US)
Pages (from-to)	750-753
Number of pages	4
Journal	Clinical Biochemistry
Volume	42
Issue number	7-8
DOIs	https://doi.org/10.1016/j.clinbiochem.2008.12.004
State	Published - May 1 2009
Externally published	Yes

ASJC Scopus subject areas

Clinical Biochemistry

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10.1016/j.clinbiochem.2008.12.004

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abstract = "Objective: To determine second trimester reference intervals for TSH and FT4. Design: Samples from 3102 subjects were tested for TPO and Tg antibodies. Methods: Elecsys E170 reference intervals for TSH and FT4 were determined using antibody-negative samples. Results: Second trimester reference intervals for TSH and FT4 were 0.18-4.07 mIU/L and 9.5-15.8 pmol/L, respectively. The Elecsys E170 TSH results were positively biased compared to ARCHITECT i2000SR results for these same samples. Conclusions: Method-specific reference intervals are required for TSH and FT4. {\textcopyright} 2008 The Canadian Society of Clinical Chemists.",

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T1 - Method specific second-trimester reference intervals for thyroid-stimulating hormone and free thyroxine

AU - Silvio, Rechelle

AU - Swapp, Karly J.

AU - La'ulu, Sonia L.

AU - Hansen-Suchy, Kara

AU - Roberts, William L.

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PY - 2009/5/1

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N2 - Objective: To determine second trimester reference intervals for TSH and FT4. Design: Samples from 3102 subjects were tested for TPO and Tg antibodies. Methods: Elecsys E170 reference intervals for TSH and FT4 were determined using antibody-negative samples. Results: Second trimester reference intervals for TSH and FT4 were 0.18-4.07 mIU/L and 9.5-15.8 pmol/L, respectively. The Elecsys E170 TSH results were positively biased compared to ARCHITECT i2000SR results for these same samples. Conclusions: Method-specific reference intervals are required for TSH and FT4. © 2008 The Canadian Society of Clinical Chemists.

AB - Objective: To determine second trimester reference intervals for TSH and FT4. Design: Samples from 3102 subjects were tested for TPO and Tg antibodies. Methods: Elecsys E170 reference intervals for TSH and FT4 were determined using antibody-negative samples. Results: Second trimester reference intervals for TSH and FT4 were 0.18-4.07 mIU/L and 9.5-15.8 pmol/L, respectively. The Elecsys E170 TSH results were positively biased compared to ARCHITECT i2000SR results for these same samples. Conclusions: Method-specific reference intervals are required for TSH and FT4. © 2008 The Canadian Society of Clinical Chemists.

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Method specific second-trimester reference intervals for thyroid-stimulating hormone and free thyroxine

Abstract

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