Michael-Michael ring closure reaction of benzyl cyanides and chalcones

M. M. Al-Arab; B. S. Ghanem; M. M. Olmstead

doi:10.1055/s-1992-26289

Michael-Michael ring closure reaction of benzyl cyanides and chalcones

M. M. Al-Arab^*, B. S. Ghanem, M. M. Olmstead

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The synthesis of a number of highly substituted cyclohexane derivatives has been accomplished in a single step reaction of benzyl cyanides and chalcones (1:2) using sodium ethoxide in anhydrous diethyl ether at room temperature to give 3-aroyl-1,2,4,6-tetraaryl-4-hydroxycyclohexanecarbonitriles. An unambiguous structural assignment was achieved from the analytical and infrared, ¹H NMR and ¹³C NMR spectroscopic data as well as X-ray crystallography.

Original language	English (US)
Pages (from-to)	1003-1006
Number of pages	4
Journal	Synthesis
Issue number	10
DOIs	https://doi.org/10.1055/s-1992-26289
State	Published - 1992
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Organic Chemistry

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title = "Michael-Michael ring closure reaction of benzyl cyanides and chalcones",

abstract = "The synthesis of a number of highly substituted cyclohexane derivatives has been accomplished in a single step reaction of benzyl cyanides and chalcones (1:2) using sodium ethoxide in anhydrous diethyl ether at room temperature to give 3-aroyl-1,2,4,6-tetraaryl-4-hydroxycyclohexanecarbonitriles. An unambiguous structural assignment was achieved from the analytical and infrared, 1H NMR and 13C NMR spectroscopic data as well as X-ray crystallography.",

author = "Al-Arab, {M. M.} and Ghanem, {B. S.} and Olmstead, {M. M.}",

year = "1992",

doi = "10.1055/s-1992-26289",

language = "English (US)",

pages = "1003--1006",

journal = "Synthesis",

issn = "0039-7881",

publisher = "Thieme Gruppe",

number = "10",

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TY - JOUR

T1 - Michael-Michael ring closure reaction of benzyl cyanides and chalcones

AU - Al-Arab, M. M.

AU - Ghanem, B. S.

AU - Olmstead, M. M.

PY - 1992

Y1 - 1992

N2 - The synthesis of a number of highly substituted cyclohexane derivatives has been accomplished in a single step reaction of benzyl cyanides and chalcones (1:2) using sodium ethoxide in anhydrous diethyl ether at room temperature to give 3-aroyl-1,2,4,6-tetraaryl-4-hydroxycyclohexanecarbonitriles. An unambiguous structural assignment was achieved from the analytical and infrared, 1H NMR and 13C NMR spectroscopic data as well as X-ray crystallography.

AB - The synthesis of a number of highly substituted cyclohexane derivatives has been accomplished in a single step reaction of benzyl cyanides and chalcones (1:2) using sodium ethoxide in anhydrous diethyl ether at room temperature to give 3-aroyl-1,2,4,6-tetraaryl-4-hydroxycyclohexanecarbonitriles. An unambiguous structural assignment was achieved from the analytical and infrared, 1H NMR and 13C NMR spectroscopic data as well as X-ray crystallography.

UR - http://www.scopus.com/inward/record.url?scp=0026712287&partnerID=8YFLogxK

U2 - 10.1055/s-1992-26289

DO - 10.1055/s-1992-26289

M3 - Article

AN - SCOPUS:0026712287

SN - 0039-7881

SP - 1003

EP - 1006

JO - Synthesis

JF - Synthesis

IS - 10

ER -

Michael-Michael ring closure reaction of benzyl cyanides and chalcones

Abstract

ASJC Scopus subject areas

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