Microarchitected 3D printed polylactic acid (PLA) nanocomposite scaffolds for biomedical applications

Fahad Alam; Vishnu Raj Shukla; K. M. Varadarajan; S. Kumar

doi:10.1016/j.jmbbm.2019.103576

Microarchitected 3D printed polylactic acid (PLA) nanocomposite scaffolds for biomedical applications

Fahad Alam, Vishnu Raj Shukla, K. M. Varadarajan, S. Kumar

Research output: Contribution to journal › Article › peer-review

128 Scopus citations

Abstract

Anti-bacterial scaffolds made of copper, bronze and silver particles filled PLA nanocomposites were realized via fused filament fabrication (FFF), additive manufacturing. The thermal, mechanical and biological characteristics including bioactivity and bactericidal properties of the scaffolds were evaluated. The incorporation of bronze particles into the neat PLA increases the elastic modulus up to 10% and 27% for samples printed in 0° and 90° configurations respectively. The stiffness increases, up to 103% for silver filled PLA nanocomposite scaffolds. The surface of scaffolds was treated with acetic acid to create a thin porous network. Significant increase (~20–25%) in the anti-bacterial properties and bioactivity (~18–100%) is attributed to the synergetic effect of reinforcement of metallic/metallic alloy particles and acid treatment. The results indicate that PLA nanocomposites could be a potential candidate for bone scaffold applications.

Original language	English (US)
Journal	Journal of the Mechanical Behavior of Biomedical Materials
Volume	103
DOIs	https://doi.org/10.1016/j.jmbbm.2019.103576
State	Published - Mar 1 2020
Externally published	Yes

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title = "Microarchitected 3D printed polylactic acid (PLA) nanocomposite scaffolds for biomedical applications",

abstract = "Anti-bacterial scaffolds made of copper, bronze and silver particles filled PLA nanocomposites were realized via fused filament fabrication (FFF), additive manufacturing. The thermal, mechanical and biological characteristics including bioactivity and bactericidal properties of the scaffolds were evaluated. The incorporation of bronze particles into the neat PLA increases the elastic modulus up to 10% and 27% for samples printed in 0° and 90° configurations respectively. The stiffness increases, up to 103% for silver filled PLA nanocomposite scaffolds. The surface of scaffolds was treated with acetic acid to create a thin porous network. Significant increase (~20–25%) in the anti-bacterial properties and bioactivity (~18–100%) is attributed to the synergetic effect of reinforcement of metallic/metallic alloy particles and acid treatment. The results indicate that PLA nanocomposites could be a potential candidate for bone scaffold applications.",

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AU - Alam, Fahad

AU - Shukla, Vishnu Raj

AU - Varadarajan, K. M.

AU - Kumar, S.

N1 - Generated from Scopus record by KAUST IRTS on 2023-09-23

PY - 2020/3/1

Y1 - 2020/3/1

N2 - Anti-bacterial scaffolds made of copper, bronze and silver particles filled PLA nanocomposites were realized via fused filament fabrication (FFF), additive manufacturing. The thermal, mechanical and biological characteristics including bioactivity and bactericidal properties of the scaffolds were evaluated. The incorporation of bronze particles into the neat PLA increases the elastic modulus up to 10% and 27% for samples printed in 0° and 90° configurations respectively. The stiffness increases, up to 103% for silver filled PLA nanocomposite scaffolds. The surface of scaffolds was treated with acetic acid to create a thin porous network. Significant increase (~20–25%) in the anti-bacterial properties and bioactivity (~18–100%) is attributed to the synergetic effect of reinforcement of metallic/metallic alloy particles and acid treatment. The results indicate that PLA nanocomposites could be a potential candidate for bone scaffold applications.

AB - Anti-bacterial scaffolds made of copper, bronze and silver particles filled PLA nanocomposites were realized via fused filament fabrication (FFF), additive manufacturing. The thermal, mechanical and biological characteristics including bioactivity and bactericidal properties of the scaffolds were evaluated. The incorporation of bronze particles into the neat PLA increases the elastic modulus up to 10% and 27% for samples printed in 0° and 90° configurations respectively. The stiffness increases, up to 103% for silver filled PLA nanocomposite scaffolds. The surface of scaffolds was treated with acetic acid to create a thin porous network. Significant increase (~20–25%) in the anti-bacterial properties and bioactivity (~18–100%) is attributed to the synergetic effect of reinforcement of metallic/metallic alloy particles and acid treatment. The results indicate that PLA nanocomposites could be a potential candidate for bone scaffold applications.

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VL - 103

JO - Journal of the Mechanical Behavior of Biomedical Materials

JF - Journal of the Mechanical Behavior of Biomedical Materials

ER -

Microarchitected 3D printed polylactic acid (PLA) nanocomposite scaffolds for biomedical applications

Abstract

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