TY - JOUR
T1 - Microfluidic device for continuous single cells analysis via Raman spectroscopy enhanced by integrated plasmonic nanodimers
AU - Perozziello, Gerardo
AU - Candeloro, Patrizio
AU - De Grazia, Antonio
AU - Esposito, Francesco
AU - Allione, Marco
AU - Coluccio, Maria Laura
AU - Tallerico, Rossana
AU - Valpapuram, Immanuel
AU - Tirinato, Luca
AU - Das, Gobind
AU - Giugni, Andrea
AU - Torre, Bruno
AU - Veltri, Pierangelo
AU - Kruhne, Ulrich
AU - Della Valle, Giuseppe
AU - Di Fabrizio, Enzo M.
N1 - KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: This work was partially supported by the European project EUROMBR (grant no. 608104), Cariplo Foundation under the project "New Frontiers in Plasmonic Nanosensing" (Grant no. 2011-0338), the project for Young researchers financed from the Ministry of Health "High Throughput analysis of cancer cells for therapy evaluation by microfluidic platforms integrating plasmonic nanodevices" (CUP J65C13001350001, project no. GR-2010-2311677) granted to the nanotechnology laboratory of the Department of Experimental and Clinical Medicine of the University "Magna Graecia" of Catanzaro.
PY - 2015/12/11
Y1 - 2015/12/11
N2 - In this work a Raman flow cytometer is presented. It consists of a microfluidic device that takes advantages of the basic principles of Raman spectroscopy and flow cytometry. The microfluidic device integrates calibrated microfluidic channels- where the cells can flow one-by-one -, allowing single cell Raman analysis. The microfluidic channel integrates plasmonic nanodimers in a fluidic trapping region. In this way it is possible to perform Enhanced Raman Spectroscopy on single cell. These allow a label-free analysis, providing information about the biochemical content of membrane and cytoplasm of the each cell. Experiments are performed on red blood cells (RBCs), peripheral blood lymphocytes (PBLs) and myelogenous leukemia tumor cells (K562). © 2015 Optical Society of America.
AB - In this work a Raman flow cytometer is presented. It consists of a microfluidic device that takes advantages of the basic principles of Raman spectroscopy and flow cytometry. The microfluidic device integrates calibrated microfluidic channels- where the cells can flow one-by-one -, allowing single cell Raman analysis. The microfluidic channel integrates plasmonic nanodimers in a fluidic trapping region. In this way it is possible to perform Enhanced Raman Spectroscopy on single cell. These allow a label-free analysis, providing information about the biochemical content of membrane and cytoplasm of the each cell. Experiments are performed on red blood cells (RBCs), peripheral blood lymphocytes (PBLs) and myelogenous leukemia tumor cells (K562). © 2015 Optical Society of America.
UR - http://hdl.handle.net/10754/621445
UR - https://www.osapublishing.org/abstract.cfm?URI=oe-24-2-A180
UR - http://www.scopus.com/inward/record.url?scp=84962090378&partnerID=8YFLogxK
U2 - 10.1364/oe.24.00a180
DO - 10.1364/oe.24.00a180
M3 - Article
SN - 1094-4087
VL - 24
SP - A180
JO - Optics Express
JF - Optics Express
IS - 2
ER -