TY - JOUR
T1 - Microfluidic platforms for cell cultures and investigations
AU - Coluccio, Maria Laura
AU - Perozziello, Gerardo
AU - Malara, Natalia
AU - Parrotta, Elvira
AU - Zhang, Peng
AU - Gentile, Francesco
AU - Limongi, Tania
AU - Raj, Pushparani Michael
AU - Cuda, Gianni
AU - Candeloro, Patrizio
AU - Di Fabrizio, Enzo M.
N1 - KAUST Repository Item: Exported on 2020-10-01
Acknowledgements: This work was supported by the project for Young researchers financed from the Italian Ministry of Health “High Throughput analysis of cancer cells for therapy evaluation by microfluidic platforms integrating plasmonic nanodevices” (CUP J65C13001350001, project No. GR-2010-2311677) granted to the nanotechnology laboratory of the Department of Experimental and Clinical Medicine of the University “Magna Graecia” of Catanzaro.
PY - 2019/1/28
Y1 - 2019/1/28
N2 - This review covers several aspects of microfluidic devices used for culturing and monitoring of both adherent and non-adherent cells, including a multitude of applications. A comparison of available platforms with high throughput analysis, automation capability, interface to sensors and integration, is reported. Aspects, such as operational versatility of the devices, are scrutinized in terms of their analytical efficacy. It is found that due to multi-functionality capability of modern microfluidics, there is big amount of experimental data obtainable from a single device, allowing complex experimental control and efficient data correlation, particularly important when biomedical studies are considered. Hence several examples on cell culture and monitoring are given in this review, including details on design of microfluidic devices with their distinctive technological peculiarities.
AB - This review covers several aspects of microfluidic devices used for culturing and monitoring of both adherent and non-adherent cells, including a multitude of applications. A comparison of available platforms with high throughput analysis, automation capability, interface to sensors and integration, is reported. Aspects, such as operational versatility of the devices, are scrutinized in terms of their analytical efficacy. It is found that due to multi-functionality capability of modern microfluidics, there is big amount of experimental data obtainable from a single device, allowing complex experimental control and efficient data correlation, particularly important when biomedical studies are considered. Hence several examples on cell culture and monitoring are given in this review, including details on design of microfluidic devices with their distinctive technological peculiarities.
UR - http://hdl.handle.net/10754/631136
UR - https://www.sciencedirect.com/science/article/pii/S016793171930019X
UR - http://www.scopus.com/inward/record.url?scp=85061449212&partnerID=8YFLogxK
U2 - 10.1016/j.mee.2019.01.004
DO - 10.1016/j.mee.2019.01.004
M3 - Article
SN - 0167-9317
VL - 208
SP - 14
EP - 28
JO - Microelectronic Engineering
JF - Microelectronic Engineering
ER -