MicroRNA Regulation of Stem Cell Fate and Reprogramming

Erika Lorenzo Vivas; Gustavo Tiscornia; Juan Carlos Izpisua Belmonte

doi:10.1002/9781118300312.ch2

MicroRNA Regulation of Stem Cell Fate and Reprogramming

Erika Lorenzo Vivas^*, Gustavo Tiscornia, Juan Carlos Izpisua Belmonte

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Stem cells are seen as a new era in medicine due to their ability to differentiate and repopulate human tissues. Studies on their biology uncovered their incredible complexity and led to the creation of induced pluripotent stem cells (iPSc). MicroRNAs (miRNAs), in the beginning seen as an oddity, have been revealed as the cornerstone in the network regulating pluripotency and differentiation, becoming essential in understanding stem cell clockworks. In this chapter we try to clarify the role of miRNAs in the pluripotency-differentiation network, as well as their importance in regenerative medicine through reprogramming techniques.

Original language	English (US)
Title of host publication	MicroRNAs in Medicine
Publisher	Wiley-Blackwell
Pages	25-40
Number of pages	16
ISBN (Electronic)	9781118300312
ISBN (Print)	9781118300398
DOIs	https://doi.org/10.1002/9781118300312.ch2
State	Published - Nov 4 2013
Externally published	Yes

Keywords

Pluripotency
Reprogramming
Stem cell
Transdifferentiation

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/9781118300312.ch2

Cite this

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doi = "10.1002/9781118300312.ch2",

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AU - Tiscornia, Gustavo

AU - Belmonte, Juan Carlos Izpisua

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AB - Stem cells are seen as a new era in medicine due to their ability to differentiate and repopulate human tissues. Studies on their biology uncovered their incredible complexity and led to the creation of induced pluripotent stem cells (iPSc). MicroRNAs (miRNAs), in the beginning seen as an oddity, have been revealed as the cornerstone in the network regulating pluripotency and differentiation, becoming essential in understanding stem cell clockworks. In this chapter we try to clarify the role of miRNAs in the pluripotency-differentiation network, as well as their importance in regenerative medicine through reprogramming techniques.

KW - Pluripotency

KW - Reprogramming

KW - Stem cell

KW - Transdifferentiation

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M3 - Chapter

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EP - 40

BT - MicroRNAs in Medicine

PB - Wiley-Blackwell

ER -

MicroRNA Regulation of Stem Cell Fate and Reprogramming

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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