TY - JOUR
T1 - Microvilli Adhesion: An Alternative Route for Nanoparticle Cell Internalization
AU - Sommi, Patrizia
AU - Vitali, Agostina
AU - Coniglio, Stefania
AU - Callegari, Daniele
AU - Barbieri, Sofia
AU - Casu, Alberto
AU - Falqui, Andrea
AU - Vigano’, Lorenzo
AU - Vigani, Barbara
AU - Ferrari, Franca
AU - Anselmi-Tamburini, Umberto
N1 - KAUST Repository Item: Exported on 2021-11-24
Acknowledgements: We are grateful to A. Ottolenghi, Department of Physics, University of Pavia, for the use of the Attune NxT cytofluorimeter; P. Pallavicini, Department of Chemistry, University of Pavia, for the use of DLS; Centro Interdipartimentale di Studi e Ricerca per la Conservazione del Patrimonio Culturale (CISRiC), University of Pavia, for providing access to HRSEM; C. Di Benedetto, King Abdullah University of Science and Technology (KAUST), for TEM sample preparation and image acquisition; and Centro Grandi Strumenti, University of Pavia, for confocal microscopy and flow cytometry (BD FACSLyric System). We thank U. Laforenza and G. Pellavio, Department of Molecular Medicine, University of Pavia, for providing us with human mesothelioma cell lines. Part of this work was financially supported by Fondazione Banca del Monte di Lombardia to U.A.-T., as well as by KAUST Baseline funding to A.F.
PY - 2021/9/29
Y1 - 2021/9/29
N2 - The cellular uptake of nanoparticles (NPs) represents a critical step in nanomedicine and a crucial point for understanding the interaction of nanomaterials with biological systems. No specific mechanism of uptake has been identified so far, as the NPs are generally incorporated by the cells through one of the few well-known endocytotic mechanisms. Here, an alternative internalization route mediated by microvilli adhesion is demonstrated. This microvillus-mediated adhesion (MMA) has been observed using ceria and magnetite NPs with a dimension of
AB - The cellular uptake of nanoparticles (NPs) represents a critical step in nanomedicine and a crucial point for understanding the interaction of nanomaterials with biological systems. No specific mechanism of uptake has been identified so far, as the NPs are generally incorporated by the cells through one of the few well-known endocytotic mechanisms. Here, an alternative internalization route mediated by microvilli adhesion is demonstrated. This microvillus-mediated adhesion (MMA) has been observed using ceria and magnetite NPs with a dimension of
UR - http://hdl.handle.net/10754/672044
UR - https://pubs.acs.org/doi/10.1021/acsnano.1c03151
UR - http://www.scopus.com/inward/record.url?scp=85117238013&partnerID=8YFLogxK
U2 - 10.1021/acsnano.1c03151
DO - 10.1021/acsnano.1c03151
M3 - Article
C2 - 34585565
SN - 1936-0851
VL - 15
SP - 15803
EP - 15814
JO - ACS Nano
JF - ACS Nano
IS - 10
ER -