Microwave-assisted solid-phase peptide synthesis utilizing N-Fmoc-protected (α-aminoacyl)benzotriazoles

Alan R. Katritzky; Niveen M. Khashab; Megumi Yoshioka; Danniebelle N. Haase; Krista R. Wilson; Jodie V. Johnson; Alfred Chung; Carrie Haskell-Luevano

doi:10.1111/j.1747-0285.2007.00584.x

Microwave-assisted solid-phase peptide synthesis utilizing N-Fmoc-protected (α-aminoacyl)benzotriazoles

Alan R. Katritzky^*, Niveen M. Khashab, Megumi Yoshioka, Danniebelle N. Haase, Krista R. Wilson, Jodie V. Johnson, Alfred Chung, Carrie Haskell-Luevano

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

A novel microwave-assisted solid-phase peptide synthesis utilizing N-Fmoc-protected(α-aminoacyl)benzotriazoles was applied in the preparation of tri-, tetra-, penta-, hexa-, and heptapeptides in 71% average crude yield.

Original language	English (US)
Pages (from-to)	465-468
Number of pages	4
Journal	Chemical Biology and Drug Design
Volume	70
Issue number	5
DOIs	https://doi.org/10.1111/j.1747-0285.2007.00584.x
State	Published - Nov 2007
Externally published	Yes

Keywords

Microwave irradiation
N-Fmoc-protected(α-aminoacyl)benzotriazole
Peptides
Rink amide resin
Solid-phase peptide synthesis

ASJC Scopus subject areas

Drug Discovery
Molecular Medicine
Biochemistry
Pharmacology
Organic Chemistry

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10.1111/j.1747-0285.2007.00584.x

Cite this

@article{a2fec76d29e3488a84c1fb946658d2fb,

title = "Microwave-assisted solid-phase peptide synthesis utilizing N-Fmoc-protected (α-aminoacyl)benzotriazoles",

abstract = "A novel microwave-assisted solid-phase peptide synthesis utilizing N-Fmoc-protected(α-aminoacyl)benzotriazoles was applied in the preparation of tri-, tetra-, penta-, hexa-, and heptapeptides in 71% average crude yield.",

keywords = "Microwave irradiation, N-Fmoc-protected(α-aminoacyl)benzotriazole, Peptides, Rink amide resin, Solid-phase peptide synthesis",

author = "Katritzky, {Alan R.} and Khashab, {Niveen M.} and Megumi Yoshioka and Haase, {Danniebelle N.} and Wilson, {Krista R.} and Johnson, {Jodie V.} and Alfred Chung and Carrie Haskell-Luevano",

year = "2007",

month = nov,

doi = "10.1111/j.1747-0285.2007.00584.x",

language = "English (US)",

volume = "70",

pages = "465--468",

journal = "Chemical Biology and Drug Design",

issn = "1747-0277",

publisher = "Blackwell",

number = "5",

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T1 - Microwave-assisted solid-phase peptide synthesis utilizing N-Fmoc-protected (α-aminoacyl)benzotriazoles

AU - Katritzky, Alan R.

AU - Khashab, Niveen M.

AU - Yoshioka, Megumi

AU - Haase, Danniebelle N.

AU - Wilson, Krista R.

AU - Johnson, Jodie V.

AU - Chung, Alfred

AU - Haskell-Luevano, Carrie

PY - 2007/11

Y1 - 2007/11

N2 - A novel microwave-assisted solid-phase peptide synthesis utilizing N-Fmoc-protected(α-aminoacyl)benzotriazoles was applied in the preparation of tri-, tetra-, penta-, hexa-, and heptapeptides in 71% average crude yield.

AB - A novel microwave-assisted solid-phase peptide synthesis utilizing N-Fmoc-protected(α-aminoacyl)benzotriazoles was applied in the preparation of tri-, tetra-, penta-, hexa-, and heptapeptides in 71% average crude yield.

KW - Microwave irradiation

KW - N-Fmoc-protected(α-aminoacyl)benzotriazole

KW - Peptides

KW - Rink amide resin

KW - Solid-phase peptide synthesis

UR - http://www.scopus.com/inward/record.url?scp=35348960404&partnerID=8YFLogxK

U2 - 10.1111/j.1747-0285.2007.00584.x

DO - 10.1111/j.1747-0285.2007.00584.x

M3 - Article

C2 - 17949361

AN - SCOPUS:35348960404

SN - 1747-0277

VL - 70

SP - 465

EP - 468

JO - Chemical Biology and Drug Design

JF - Chemical Biology and Drug Design

IS - 5

ER -

Microwave-assisted solid-phase peptide synthesis utilizing N-Fmoc-protected (α-aminoacyl)benzotriazoles

Abstract

Keywords

ASJC Scopus subject areas

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