TY - JOUR
T1 - Microwave-Induced Chemotoxicity of Polydopamine-Coated Magnetic Nanocubes
AU - Julfakyan, Khachatur
AU - Fatieiev, Yevhen
AU - Alsaiari, Shahad K.
AU - Deng, Lin
AU - Ezzeddine, Alaa
AU - Zhang, Dingyuan
AU - Rotello, Vincent M.
AU - Khashab, Niveen M.
N1 - KAUST Repository Item: Exported on 2020-10-01
PY - 2015/8/6
Y1 - 2015/8/6
N2 - Polydopamine-coated FeCo nanocubes (PDFCs) were successfully synthesized and tested under microwave irradiation of 2.45 GHz frequency and 0.86 W/cm2 power. These particles were found to be non-toxic in the absence of irradiation, but gained significant toxicity upon irradiation. Interestingly, no increase in relative heating rate was observed when the PDFCs were irradiated in solution, eliminating nanoparticle (NP)-induced thermal ablation as the source of toxicity. Based on these studies, we propose that microwave-induced redox processes generate the observed toxicity. © 2015 by the authors; licensee MDPI, Basel, Switzerland.
AB - Polydopamine-coated FeCo nanocubes (PDFCs) were successfully synthesized and tested under microwave irradiation of 2.45 GHz frequency and 0.86 W/cm2 power. These particles were found to be non-toxic in the absence of irradiation, but gained significant toxicity upon irradiation. Interestingly, no increase in relative heating rate was observed when the PDFCs were irradiated in solution, eliminating nanoparticle (NP)-induced thermal ablation as the source of toxicity. Based on these studies, we propose that microwave-induced redox processes generate the observed toxicity. © 2015 by the authors; licensee MDPI, Basel, Switzerland.
UR - http://hdl.handle.net/10754/594191
UR - http://www.mdpi.com/1422-0067/16/8/18283
UR - http://www.scopus.com/inward/record.url?scp=84938823498&partnerID=8YFLogxK
U2 - 10.3390/ijms160818283
DO - 10.3390/ijms160818283
M3 - Article
C2 - 26287162
SN - 1422-0067
VL - 16
SP - 18283
EP - 18292
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 8
ER -