TY - JOUR
T1 - Mini-review: Marine natural products and their synthetic analogs as antifouling compounds: 2009–2014
AU - Qian, Pei-Yuan
AU - Li, Zhongrui
AU - Xu, Ying
AU - Li, Yongxin
AU - Fusetani, Nobuhiro
N1 - KAUST Repository Item: Exported on 2021-03-31
Acknowledged KAUST grant number(s): SA-C0040/UK-C0016
Acknowledgements: This work was supported by a grant [DY125-15-T-02] from the China Ocean Mineral Resources Research and Development Association, a grant [SIDSSE-201206] from the Sanya Institute of Deep Sea Science and Engineering, a GRC grant [GRF661611] from Hong Kong Special Administrative Region, and award [SA-C0040/UK-C0016] from King Abdullah University of Science and Technology.
This publication acknowledges KAUST support, but has no KAUST affiliated authors.
PY - 2015/1/26
Y1 - 2015/1/26
N2 - This review covers 214 marine natural compounds and 23 of their synthetic analogs, which were discovered and/or synthesized from mid-2009 to August 2014. The antifouling (AF) compounds reported have medium to high bioactivity (with a threshold of EC50 < 15.0 mg ml−1). Among these compounds, 82 natural compounds were identified as new structures. All the compounds are marine-derived, demonstrating that marine organisms are prolific and promising sources of natural products that may be developed as environmentally friendly antifoulants. However, this mini-review excludes more than 200 compounds that were also reported as AF compounds but with rather weak bioactivity during the same period. Also excluded are terrestrial-derived AF compounds reported during the last five years. A brief discussion on current challenges in AF compound research is also provided to reflect the authors’ own views in terms of future research directions.
AB - This review covers 214 marine natural compounds and 23 of their synthetic analogs, which were discovered and/or synthesized from mid-2009 to August 2014. The antifouling (AF) compounds reported have medium to high bioactivity (with a threshold of EC50 < 15.0 mg ml−1). Among these compounds, 82 natural compounds were identified as new structures. All the compounds are marine-derived, demonstrating that marine organisms are prolific and promising sources of natural products that may be developed as environmentally friendly antifoulants. However, this mini-review excludes more than 200 compounds that were also reported as AF compounds but with rather weak bioactivity during the same period. Also excluded are terrestrial-derived AF compounds reported during the last five years. A brief discussion on current challenges in AF compound research is also provided to reflect the authors’ own views in terms of future research directions.
UR - http://hdl.handle.net/10754/668400
UR - http://www.tandfonline.com/doi/abs/10.1080/08927014.2014.997226
UR - http://www.scopus.com/inward/record.url?scp=84961289475&partnerID=8YFLogxK
U2 - 10.1080/08927014.2014.997226
DO - 10.1080/08927014.2014.997226
M3 - Article
SN - 0892-7014
VL - 31
SP - 101
EP - 122
JO - Biofouling
JF - Biofouling
IS - 1
ER -