TY - JOUR
T1 - Mining the jewels of the cortex's crowning mystery
AU - Ibrahim, Leena A.
AU - Schuman, Ben
AU - Bandler, Rachel
AU - Rudy, Bernardo
AU - Fishell, Gord
N1 - Generated from Scopus record by KAUST IRTS on 2022-09-13
PY - 2020/8/1
Y1 - 2020/8/1
N2 - Neocortical Layer 1 consists of a dense mesh of excitatory and inhibitory axons, dendrites of pyramidal neurons, as well as neuromodulatory inputs from diverse brain regions. Layer 1 also consists of a sparse population of inhibitory interneurons, which are appropriately positioned to receive and integrate the information from these regions of the brain and modulate cortical processing. Despite being among the sparsest neuronal population in the cortex, Layer 1 interneurons perform powerful computations and have elaborate morphologies. Here we review recent studies characterizing their origin, morphology, physiology, and molecular profiles, as well as their connectivity and in vivo response properties.
AB - Neocortical Layer 1 consists of a dense mesh of excitatory and inhibitory axons, dendrites of pyramidal neurons, as well as neuromodulatory inputs from diverse brain regions. Layer 1 also consists of a sparse population of inhibitory interneurons, which are appropriately positioned to receive and integrate the information from these regions of the brain and modulate cortical processing. Despite being among the sparsest neuronal population in the cortex, Layer 1 interneurons perform powerful computations and have elaborate morphologies. Here we review recent studies characterizing their origin, morphology, physiology, and molecular profiles, as well as their connectivity and in vivo response properties.
UR - https://linkinghub.elsevier.com/retrieve/pii/S0959438820300842
UR - http://www.scopus.com/inward/record.url?scp=85085273051&partnerID=8YFLogxK
U2 - 10.1016/j.conb.2020.04.005
DO - 10.1016/j.conb.2020.04.005
M3 - Article
SN - 1873-6882
VL - 63
SP - 154
EP - 161
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
ER -