TY - JOUR
T1 - Mitochondrial regulation in pluripotent stem cells
AU - Xu, Xiuling
AU - Duan, Shunlei
AU - Yi, Fei
AU - Ocampo, Alejandro
AU - Liu, Guang Hui
AU - Izpisua Belmonte, Juan Carlos
N1 - Funding Information:
G.-H.L. is supported by the Strategic Priority Research Program of the Chinese Academy of Sciences (XDA01020312), NSFC (81271266, 31222039), the Thousand Young Talents program of China, National Laboratory of Biomacromolecules (2013kf05, 2013kf11), and State Key Laboratory of Drug Research (SIMM1302KF-17). X.X. was supported by NSFC (31201111). J.C.I.B. was supported by TERCEL-ISCIII-MINECO, Fundacion Cellex, G. Harold and Leila Y. Mathers Charitable Foundation, The Leona M. and Harry B. Helmsley Charitable Trust, The Glenn Center for Aging Research and The Ellison Medical Foundation.
PY - 2013/9/3
Y1 - 2013/9/3
N2 - Due to their fundamental role in energy production, mitochondria have been traditionally known as the powerhouse of the cell. Recent discoveries have suggested crucial roles of mitochondria in the maintenance of pluripotency, differentiation, and reprogramming of induced pluripotent stem cells (iPSCs). While glycolytic energy production is observed at pluripotent states, an increase in mitochondrial oxidative phosphorylation is necessary for cell differentiation. Consequently, a transition from somatic mitochondrial oxidative metabolism to glycolysis seems to be required for successful reprogramming. Future research aiming to dissect the roles of mitochondria in the establishment and homeostasis of pluripotency, as well as combining cell reprogramming with gene editing technologies, may unearth novel insights into our understanding of mitochondrial diseases and aging.
AB - Due to their fundamental role in energy production, mitochondria have been traditionally known as the powerhouse of the cell. Recent discoveries have suggested crucial roles of mitochondria in the maintenance of pluripotency, differentiation, and reprogramming of induced pluripotent stem cells (iPSCs). While glycolytic energy production is observed at pluripotent states, an increase in mitochondrial oxidative phosphorylation is necessary for cell differentiation. Consequently, a transition from somatic mitochondrial oxidative metabolism to glycolysis seems to be required for successful reprogramming. Future research aiming to dissect the roles of mitochondria in the establishment and homeostasis of pluripotency, as well as combining cell reprogramming with gene editing technologies, may unearth novel insights into our understanding of mitochondrial diseases and aging.
UR - http://www.scopus.com/inward/record.url?scp=84883489939&partnerID=8YFLogxK
U2 - 10.1016/j.cmet.2013.06.005
DO - 10.1016/j.cmet.2013.06.005
M3 - Review article
C2 - 23850316
AN - SCOPUS:84883489939
SN - 1550-4131
VL - 18
SP - 325
EP - 332
JO - Cell Metabolism
JF - Cell Metabolism
IS - 3
ER -