TY - JOUR

T1 - Model reduction using a posteriori analysis

AU - Whiteley, Jonathan P.

N1 - KAUST Repository Item: Exported on 2020-10-01
Acknowledged KAUST grant number(s): KUK-C1-013-04
Acknowledgements: This publication is based on work supported by Award No. KUK-C1-013-04, made by King Abdullah University of Science and Technology (KAUST).
This publication acknowledges KAUST support, but has no KAUST affiliated authors.

PY - 2010/5

Y1 - 2010/5

N2 - Mathematical models in biology and physiology are often represented by large systems of non-linear ordinary differential equations. In many cases, an observed behaviour may be written as a linear functional of the solution of this system of equations. A technique is presented in this study for automatically identifying key terms in the system of equations that are responsible for a given linear functional of the solution. This technique is underpinned by ideas drawn from a posteriori error analysis. This concept has been used in finite element analysis to identify regions of the computational domain and components of the solution where a fine computational mesh should be used to ensure accuracy of the numerical solution. We use this concept to identify regions of the computational domain and components of the solution where accurate representation of the mathematical model is required for accuracy of the functional of interest. The technique presented is demonstrated by application to a model problem, and then to automatically deduce known results from a cell-level cardiac electrophysiology model. © 2010 Elsevier Inc.

AB - Mathematical models in biology and physiology are often represented by large systems of non-linear ordinary differential equations. In many cases, an observed behaviour may be written as a linear functional of the solution of this system of equations. A technique is presented in this study for automatically identifying key terms in the system of equations that are responsible for a given linear functional of the solution. This technique is underpinned by ideas drawn from a posteriori error analysis. This concept has been used in finite element analysis to identify regions of the computational domain and components of the solution where a fine computational mesh should be used to ensure accuracy of the numerical solution. We use this concept to identify regions of the computational domain and components of the solution where accurate representation of the mathematical model is required for accuracy of the functional of interest. The technique presented is demonstrated by application to a model problem, and then to automatically deduce known results from a cell-level cardiac electrophysiology model. © 2010 Elsevier Inc.

UR - http://hdl.handle.net/10754/598851

UR - https://linkinghub.elsevier.com/retrieve/pii/S0025556410000246

UR - http://www.scopus.com/inward/record.url?scp=77951467252&partnerID=8YFLogxK

U2 - 10.1016/j.mbs.2010.01.008

DO - 10.1016/j.mbs.2010.01.008

M3 - Article

C2 - 20117117

SN - 0025-5564

VL - 225

SP - 44

EP - 52

JO - Mathematical Biosciences

JF - Mathematical Biosciences

IS - 1

ER -