Molded Rigid Polymer Monoliths as Separation Media for Capillary Electrochromatography

Eric C. Peters; Miroslav Petro; Frantisek Svec; Jean M.J. Fréchet

doi:10.1021/ac970377w

Molded Rigid Polymer Monoliths as Separation Media for Capillary Electrochromatography

Eric C. Peters, Miroslav Petro, Frantisek Svec, Jean M.J. Fréchet^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

451 Scopus citations

Abstract

Rigid, monolithic capillary columns for reversed-phase electrochromatography have been prepared within the confines of untreated fused-silica capillaries in a single step by a simple copolymerization of ethylene dimethacrylate, butyl methacrylate, and 2-acrylamido-2-methyl-1-propanesulfonic acid in the presence of a porogenic solvent. The composition of the specifically designed ternary porogenic solvent allows fine control of the porous properties of me monolithic material over a broad range. While the electroosmotic flow through these capillary columns increases with both increasing pore size of the monolith and content of charged functionalities, better chromatographic properties have been observed for monoliths with larger surface area and hydrophobicity. Using this technique, monolithic capillary columns with an efficiency higher than 120 000 plates/m have been easily obtained.

Original language	English (US)
Pages (from-to)	3646-3649
Number of pages	4
Journal	ANALYTICAL CHEMISTRY
Volume	69
Issue number	17
DOIs	https://doi.org/10.1021/ac970377w
State	Published - Sep 1 1997
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry

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title = "Molded Rigid Polymer Monoliths as Separation Media for Capillary Electrochromatography",

abstract = "Rigid, monolithic capillary columns for reversed-phase electrochromatography have been prepared within the confines of untreated fused-silica capillaries in a single step by a simple copolymerization of ethylene dimethacrylate, butyl methacrylate, and 2-acrylamido-2-methyl-1-propanesulfonic acid in the presence of a porogenic solvent. The composition of the specifically designed ternary porogenic solvent allows fine control of the porous properties of me monolithic material over a broad range. While the electroosmotic flow through these capillary columns increases with both increasing pore size of the monolith and content of charged functionalities, better chromatographic properties have been observed for monoliths with larger surface area and hydrophobicity. Using this technique, monolithic capillary columns with an efficiency higher than 120 000 plates/m have been easily obtained.",

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T1 - Molded Rigid Polymer Monoliths as Separation Media for Capillary Electrochromatography

AU - Peters, Eric C.

AU - Petro, Miroslav

AU - Svec, Frantisek

AU - Fréchet, Jean M.J.

PY - 1997/9/1

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N2 - Rigid, monolithic capillary columns for reversed-phase electrochromatography have been prepared within the confines of untreated fused-silica capillaries in a single step by a simple copolymerization of ethylene dimethacrylate, butyl methacrylate, and 2-acrylamido-2-methyl-1-propanesulfonic acid in the presence of a porogenic solvent. The composition of the specifically designed ternary porogenic solvent allows fine control of the porous properties of me monolithic material over a broad range. While the electroosmotic flow through these capillary columns increases with both increasing pore size of the monolith and content of charged functionalities, better chromatographic properties have been observed for monoliths with larger surface area and hydrophobicity. Using this technique, monolithic capillary columns with an efficiency higher than 120 000 plates/m have been easily obtained.

AB - Rigid, monolithic capillary columns for reversed-phase electrochromatography have been prepared within the confines of untreated fused-silica capillaries in a single step by a simple copolymerization of ethylene dimethacrylate, butyl methacrylate, and 2-acrylamido-2-methyl-1-propanesulfonic acid in the presence of a porogenic solvent. The composition of the specifically designed ternary porogenic solvent allows fine control of the porous properties of me monolithic material over a broad range. While the electroosmotic flow through these capillary columns increases with both increasing pore size of the monolith and content of charged functionalities, better chromatographic properties have been observed for monoliths with larger surface area and hydrophobicity. Using this technique, monolithic capillary columns with an efficiency higher than 120 000 plates/m have been easily obtained.

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Molded Rigid Polymer Monoliths as Separation Media for Capillary Electrochromatography

Abstract

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