TY - JOUR
T1 - Molecular diagnostic alterations in squamous cell carcinoma of the head and neck and potential diagnostic applications
AU - Hunt, Jennifer L.
AU - Barnes, Leon
AU - Lewis, James S.
AU - Mahfouz, Magdy E.
AU - Slootweg, Pieter J.
AU - Thompson, Lester D.R.
AU - Cardesa, Antonio
AU - Devaney, Kenneth O.
AU - Gnepp, Douglas R.
AU - Westra, William H.
AU - Rodrigo, Juan P.
AU - Woolgar, Julia A.
AU - Rinaldo, Alessandra
AU - Triantafyllou, Asterios
AU - Takes, Robert P.
AU - Ferlito, Alfio
N1 - Generated from Scopus record by KAUST IRTS on 2023-09-25
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Head and neck squamous cell carcinoma (HNSCC) is a common malignancy that continues to be difficult to treat and cure. In many organ systems and tumor types, there have been significant advances in the understanding of the molecular basis for tumorigenesis, disease progression and genetic implications for therapeutics. Although tumorigenesis pathways and the molecular etiologies of HNSCC have been extensively studied, there are still very few diagnostic clinical applications used in practice today. This review discusses current clinically applicable molecular markers, including viral detection of Epstein-Barr virus and human papillomavirus, and molecular targets that are used in diagnosis and management of HNSCC. The common oncogenes EGFR, RAS, CCND1, BRAF, and PIK3CA and tumor suppressor genes p53, CDKN2A and NOTCH are discussed for their associations with HNSCC. Discussion of markers with potential future applications is also included, with a focus on molecular alterations associated with targeted therapy resistance. © Springer-Verlag 2013.
AB - Head and neck squamous cell carcinoma (HNSCC) is a common malignancy that continues to be difficult to treat and cure. In many organ systems and tumor types, there have been significant advances in the understanding of the molecular basis for tumorigenesis, disease progression and genetic implications for therapeutics. Although tumorigenesis pathways and the molecular etiologies of HNSCC have been extensively studied, there are still very few diagnostic clinical applications used in practice today. This review discusses current clinically applicable molecular markers, including viral detection of Epstein-Barr virus and human papillomavirus, and molecular targets that are used in diagnosis and management of HNSCC. The common oncogenes EGFR, RAS, CCND1, BRAF, and PIK3CA and tumor suppressor genes p53, CDKN2A and NOTCH are discussed for their associations with HNSCC. Discussion of markers with potential future applications is also included, with a focus on molecular alterations associated with targeted therapy resistance. © Springer-Verlag 2013.
UR - http://link.springer.com/10.1007/s00405-013-2400-9
UR - http://www.scopus.com/inward/record.url?scp=84899049430&partnerID=8YFLogxK
U2 - 10.1007/s00405-013-2400-9
DO - 10.1007/s00405-013-2400-9
M3 - Article
SN - 1434-4726
VL - 271
SP - 211
EP - 223
JO - European Archives of Oto-Rhino-Laryngology
JF - European Archives of Oto-Rhino-Laryngology
IS - 2
ER -
