Monolithic stationary phases for capillary electrochromatography based on synthetic polymers: Designs and applications

Frantisek Svec, Eric C. Peters, David Sýkora, Cong Yu, Jean M.J. Fréchet*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

144 Scopus citations


Monolithic materials have quickly become a well-established stationary phase format in the field of capillary electrochromatography (CEC). Both the simplicity of their in situ preparation method and the large variety of readily available chemistries make the monolithic separation media an attractive alternative to capillary columns packed with particulate materials. This review summarizes the contributions of numerous groups working in this rapidly growing area, with a focus on monolithic capillary columns prepared from synthetic polymers. Various approaches employed for the preparation of the monoliths are detailed, and where available, the material properties of the resulting monolithic capillary columns are shown. Their chromatographic performance is demonstrated by numerous separations of different analyte mixtures in variety of modes. Although detailed studies of the effect of polymer properties on the analytical performance of monolithic capillaries remain scarce at this early stage of their development, this review also discusses some important relationships such as the effect of pore size on the separation performance in more detail.

Original languageEnglish (US)
Pages (from-to)3-18
Number of pages16
JournalHRC Journal of High Resolution Chromatography
Issue number1
StatePublished - 2000
Externally publishedYes


  • Capillary electrochromatography
  • Monolithic columns
  • Stationary phase
  • Synthetic polymers

ASJC Scopus subject areas

  • General Chemical Engineering


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