Multi-responsive polymeric microcontainers for potential biomedical applications: Synthesis and functionality evaluation

Panayiotis Bilalis, Eleni K. Efthimiadou, Alexandros Chatzipavlidis, Nikos Boukos, George C. Kordas*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Temperature and pH responsive poly(N-isopropylacrylamide-co-methacrylic acid) (P(NIPAAm-co-MAA)) microcontainers with encapsulated magnetic nanoparticles in the shell were prepared by a two-stage distillation precipitation polymerization. PMAA@Fe 3O 4/P(NIPAAm-co-MAA) core-shell nanoparticles were synthesized by the second-stage polymerization of NIPAAm, MAA and N, N′-methylenebisacrylamide as crosslinker in the presence of magnetic nanoparticles and PMAA as core. These novel triple-functional microcontainers were prepared by selective removal of the PMAA core in water. Daunorubicin hydrochloride (DNR) was loaded into the microcontainers and the release profile was studied by UV-visible spectroscopy. The synthesized nanostructures were characterized with transmission and scanning electron microscopy, X-ray diffraction and Fourier transform infrared spectroscopy. The magnetic properties were evaluated by vibrating sample magnetometry. The shrink and swelling behavior was studied by dynamic light scattering.

Original languageEnglish (US)
Pages (from-to)888-894
Number of pages7
JournalPolymer International
Issue number6
StatePublished - Jun 2012
Externally publishedYes


  • Daunorubicin
  • Distillation precipitation polymerization
  • Magnetic nanoparticles
  • Microcontainers
  • PH sensitive
  • Thermosensitive

ASJC Scopus subject areas

  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry


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