@article{ad7e552c652a425bbc1b5115860f3f0c,
title = "MYC as a driver of stochastic chromatin networks: implications for the fitness of cancer cells",
abstract = "Abstract The relationship between stochastic transcriptional bursts and dynamic 3D chromatin states is not well understood. Using an innovated, ultra-sensitive technique, we address here enigmatic features underlying the communications between MYC and its enhancers in relation to the transcriptional process. MYC thus interacts with its flanking enhancers in a mutually exclusive manner documenting that enhancer hubs impinging on MYC detected in large cell populations likely do not exist in single cells. Dynamic encounters with pathologically activated enhancers responsive to a range of environmental cues, involved",
author = "Noriyuki Sumida and Sifakis, {Emmanouil G} and Kiani, {Narsis A} and Anna Lewandowska Ronnegren and Scholz, {Barbara A} and Johanna Vestlund and David Gomez-Cabrero and Jesper Tegner and Anita G{\"o}nd{\"o}r and Rolf Ohlsson",
note = "KAUST Repository Item: Exported on 2020-10-19 Acknowledgements: The authors would like to acknowledge initial assistance from Drs Alejandro Woodbridge and Peter J Svensson as well as support from Science for Life Laboratory, the National Genomics Infrastructure, NGI, and Uppmax for providing assistance in massive parallel sequencing and computational infrastructure as well as the extensive data sets from ENCODE.",
year = "2020",
month = oct,
day = "11",
doi = "10.1093/nar/gkaa817",
language = "English (US)",
journal = "Nucleic Acids Research",
issn = "0305-1048",
publisher = "OXFORD UNIV PRESS",
}
