"Nail" and "comb" effects of cholesterol modified NIPAm oligomers on cancer targeting liposomes

Wengang Li; Lin Deng; Basem Moosa; Guangchao Wang; Afnan Mashat; Niveen M. Khashab

doi:10.1039/c3bm60222b

"Nail" and "comb" effects of cholesterol modified NIPAm oligomers on cancer targeting liposomes

Wengang Li, Lin Deng, Basem Moosa, Guangchao Wang, Afnan Mashat, Niveen M. Khashab

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Thermosensitive liposomes are a promising approach to controlled release and reduced drug cytotoxicity. Low molecular weight N-isopropylacrylamide (NIPAm) oligomers (NOs) with different architectures (main chain NOs (MCNOs) and side chain NOs (SCNOs)) were synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization and radical polymerization and then separately used to prepare thermosensitive liposomes. A more controlled and enhanced release was observed for both NO liposomes compared to pristine ones. Two release mechanisms depending on the oligomer architecture, namely "nail" for MCNOs and "comb" for SCNOs, are proposed. In addition to thermosensitivity, the cancer targeting property of NO liposomes was achieved by further biotinylation of the delivery system. © The Royal Society of Chemistry.

Original language	English (US)
Pages (from-to)	476
Journal	Biomaterials Science
Volume	2
Issue number	4
DOIs	https://doi.org/10.1039/c3bm60222b
State	Published - 2014

ASJC Scopus subject areas

Biomedical Engineering
General Materials Science

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/c3bm60222b

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title = "{"}Nail{"} and {"}comb{"} effects of cholesterol modified NIPAm oligomers on cancer targeting liposomes",

abstract = "Thermosensitive liposomes are a promising approach to controlled release and reduced drug cytotoxicity. Low molecular weight N-isopropylacrylamide (NIPAm) oligomers (NOs) with different architectures (main chain NOs (MCNOs) and side chain NOs (SCNOs)) were synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization and radical polymerization and then separately used to prepare thermosensitive liposomes. A more controlled and enhanced release was observed for both NO liposomes compared to pristine ones. Two release mechanisms depending on the oligomer architecture, namely {"}nail{"} for MCNOs and {"}comb{"} for SCNOs, are proposed. In addition to thermosensitivity, the cancer targeting property of NO liposomes was achieved by further biotinylation of the delivery system. {\textcopyright} The Royal Society of Chemistry.",

author = "Wengang Li and Lin Deng and Basem Moosa and Guangchao Wang and Afnan Mashat and Khashab, {Niveen M.}",

note = "KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: This research is fully sponsored by King Abdullah University of Science and Technology (KAUST).",

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doi = "10.1039/c3bm60222b",

language = "English (US)",

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T1 - "Nail" and "comb" effects of cholesterol modified NIPAm oligomers on cancer targeting liposomes

AU - Li, Wengang

AU - Deng, Lin

AU - Moosa, Basem

AU - Wang, Guangchao

AU - Mashat, Afnan

AU - Khashab, Niveen M.

N1 - KAUST Repository Item: Exported on 2020-10-01 Acknowledgements: This research is fully sponsored by King Abdullah University of Science and Technology (KAUST).

PY - 2014

Y1 - 2014

N2 - Thermosensitive liposomes are a promising approach to controlled release and reduced drug cytotoxicity. Low molecular weight N-isopropylacrylamide (NIPAm) oligomers (NOs) with different architectures (main chain NOs (MCNOs) and side chain NOs (SCNOs)) were synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization and radical polymerization and then separately used to prepare thermosensitive liposomes. A more controlled and enhanced release was observed for both NO liposomes compared to pristine ones. Two release mechanisms depending on the oligomer architecture, namely "nail" for MCNOs and "comb" for SCNOs, are proposed. In addition to thermosensitivity, the cancer targeting property of NO liposomes was achieved by further biotinylation of the delivery system. © The Royal Society of Chemistry.

AB - Thermosensitive liposomes are a promising approach to controlled release and reduced drug cytotoxicity. Low molecular weight N-isopropylacrylamide (NIPAm) oligomers (NOs) with different architectures (main chain NOs (MCNOs) and side chain NOs (SCNOs)) were synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization and radical polymerization and then separately used to prepare thermosensitive liposomes. A more controlled and enhanced release was observed for both NO liposomes compared to pristine ones. Two release mechanisms depending on the oligomer architecture, namely "nail" for MCNOs and "comb" for SCNOs, are proposed. In addition to thermosensitivity, the cancer targeting property of NO liposomes was achieved by further biotinylation of the delivery system. © The Royal Society of Chemistry.

UR - http://hdl.handle.net/10754/563177

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DO - 10.1039/c3bm60222b

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JO - Biomaterials Science

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IS - 4

ER -

"Nail" and "comb" effects of cholesterol modified NIPAm oligomers on cancer targeting liposomes

Abstract

ASJC Scopus subject areas

UN SDGs

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