TY - JOUR
T1 - Nano-Strategies for Lignin Biomaterials toward Cancer Therapy
AU - Sathasivam, Thenapakiam
AU - Kai, Jing
AU - Sugiarto, Sigit
AU - Yu, Yong
AU - Soo, Debbie Xiang Yun
AU - Zhu, Qiang
AU - Merzaban, Jasmeen
AU - Kai, Dan
N1 - Funding Information:
T.S. and J.K. contributed equally to this work. The authors gratefully acknowledge the financial support from CDA (Project No. CDA 202D800033), Agency for Science, Technology and Research (A*STAR).
Publisher Copyright:
© 2023 Wiley-VCH GmbH.
PY - 2023/7/27
Y1 - 2023/7/27
N2 - Lignin is a nontoxic and biocompatible biopolymer with many promising characteristics, including a high tensile strength and antioxidant properties. This natural polymer can be processed through several chemical methods and modified into lignin nanomaterials for potential biomedical applications. This review summarizes the latest developments in nanolignin (NL)-based biomaterials for cancer therapy; various NL applications related to cancer therapy are considered, including drug and gene delivery, biosensing, bioimaging, and tissue engineering. The manuscript also outlines the potential use of these materials to improve the therapeutic potency of chemotherapeutic drugs by decreasing their dose and reducing their adverse effects. Due to its high surface area-to-volume ratio and the easy modification of its chemical components, NL could serve as an appropriate matrix for the binding and controlled release of various pharmaceutical agents. Moreover, the challenges in the utilization of NL-based materials for cancer therapy are discussed, along with the prospects of advances in such nanomaterials for medical research applications.
AB - Lignin is a nontoxic and biocompatible biopolymer with many promising characteristics, including a high tensile strength and antioxidant properties. This natural polymer can be processed through several chemical methods and modified into lignin nanomaterials for potential biomedical applications. This review summarizes the latest developments in nanolignin (NL)-based biomaterials for cancer therapy; various NL applications related to cancer therapy are considered, including drug and gene delivery, biosensing, bioimaging, and tissue engineering. The manuscript also outlines the potential use of these materials to improve the therapeutic potency of chemotherapeutic drugs by decreasing their dose and reducing their adverse effects. Due to its high surface area-to-volume ratio and the easy modification of its chemical components, NL could serve as an appropriate matrix for the binding and controlled release of various pharmaceutical agents. Moreover, the challenges in the utilization of NL-based materials for cancer therapy are discussed, along with the prospects of advances in such nanomaterials for medical research applications.
KW - 3D printing
KW - antioxidants
KW - drug delivery
KW - lignocellulose
KW - nanotechnology
KW - tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=85152552774&partnerID=8YFLogxK
U2 - 10.1002/adhm.202300024
DO - 10.1002/adhm.202300024
M3 - Review article
C2 - 36964966
AN - SCOPUS:85152552774
SN - 2192-2640
VL - 12
JO - Advanced healthcare materials
JF - Advanced healthcare materials
IS - 19
M1 - 2300024
ER -
