Nanocrystallization of poorly water soluble drugs for parenteral administration

Foziyah Zakir; Himanshu Sharma; Karandeep Kaur; Basant Malik; Bhuvaneshwer Vaidya; Amit K. Goyal; S. P. Vyas

doi:10.1166/jbn.2011.1234

Nanocrystallization of poorly water soluble drugs for parenteral administration

Foziyah Zakir, Himanshu Sharma, Karandeep Kaur, Basant Malik, Bhuvaneshwer Vaidya, Amit K. Goyal, S. P. Vyas

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Approximately 50% active substances discovered by combinatorial chemistry and high-throughput screening show poor solubility in water. Out of various available approaches "Nanoedege technology" (Combination of Precipitation and Homogenization) was selected. Amphotericin B (Amp B) was used as a model drug. Three different preparations of Amp B were produced by using three different surfactants Tween80, Pluronic F68, Soya Lecithin and assessed for their efficacy and stability. In this study the Amp B nanosuspension formulation, with the smaller particle size, can be effectively produced with the Nanoedge Method. The pharmacokinetic profiles of Amp B when given in the nanosuspension formulation were different compared to the corresponding raw drug. Copyright © 2011 American Scientific Publishers All rights reserved.

Original language	English (US)
Pages (from-to)	127-129
Number of pages	3
Journal	Journal of Biomedical Nanotechnology
Volume	7
Issue number	1
DOIs	https://doi.org/10.1166/jbn.2011.1234
State	Published - Jan 1 2011
Externally published	Yes

ASJC Scopus subject areas

Biomedical Engineering
Bioengineering
Pharmaceutical Science
General Materials Science
Medicine (miscellaneous)

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10.1166/jbn.2011.1234

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AU - Kaur, Karandeep

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AU - Vaidya, Bhuvaneshwer

AU - Goyal, Amit K.

AU - Vyas, S. P.

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Nanocrystallization of poorly water soluble drugs for parenteral administration

Abstract

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