Nanofiber in transmucosal drug delivery

Amar Deepak; Amit Kumar Goyal; Goutam Rath

doi:10.1016/j.jddst.2017.11.008

Nanofiber in transmucosal drug delivery

Amar Deepak, Amit Kumar Goyal, Goutam Rath

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Abstract

Transmucosal route owing to its diverse anatomy and physiology offers numerous advantages for local and systemic delivery of therapeutics. Irrespective of several advantages narrow absorption window and poor retention time of carrier system are the major challenges to achieve desired therapeutic response. Nanofiber due to its unique surface properties provides numerous opportunities to overcome the limitations of conventional vehicles. In this review, the benefits of nanofiber as a carrier system for transmucosal drug delivery are discussed. The aim is to provide detailed understanding of functional features of electrospun nanofiber that make it suitable for transmucosal drug delivery. Review intends to illustrate the potential of nanofibers to deliver drugs via various transmucosal sites like nasal mucosa, intra vaginal and ocular. The review also discusses the current status of nanofiber and explores the benefits of various research works and concludes their results.

Original language	English (US)
Pages (from-to)	379-387
Number of pages	9
Journal	Journal of Drug Delivery Science and Technology
Volume	43
DOIs	https://doi.org/10.1016/j.jddst.2017.11.008
State	Published - Feb 1 2018
Externally published	Yes

ASJC Scopus subject areas

Pharmaceutical Science

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10.1016/j.jddst.2017.11.008

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abstract = "Transmucosal route owing to its diverse anatomy and physiology offers numerous advantages for local and systemic delivery of therapeutics. Irrespective of several advantages narrow absorption window and poor retention time of carrier system are the major challenges to achieve desired therapeutic response. Nanofiber due to its unique surface properties provides numerous opportunities to overcome the limitations of conventional vehicles. In this review, the benefits of nanofiber as a carrier system for transmucosal drug delivery are discussed. The aim is to provide detailed understanding of functional features of electrospun nanofiber that make it suitable for transmucosal drug delivery. Review intends to illustrate the potential of nanofibers to deliver drugs via various transmucosal sites like nasal mucosa, intra vaginal and ocular. The review also discusses the current status of nanofiber and explores the benefits of various research works and concludes their results.",

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Nanofiber in transmucosal drug delivery

Abstract

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