Nanofiber in transmucosal drug delivery

Amar Deepak, Amit Kumar Goyal, Goutam Rath

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Transmucosal route owing to its diverse anatomy and physiology offers numerous advantages for local and systemic delivery of therapeutics. Irrespective of several advantages narrow absorption window and poor retention time of carrier system are the major challenges to achieve desired therapeutic response. Nanofiber due to its unique surface properties provides numerous opportunities to overcome the limitations of conventional vehicles. In this review, the benefits of nanofiber as a carrier system for transmucosal drug delivery are discussed. The aim is to provide detailed understanding of functional features of electrospun nanofiber that make it suitable for transmucosal drug delivery. Review intends to illustrate the potential of nanofibers to deliver drugs via various transmucosal sites like nasal mucosa, intra vaginal and ocular. The review also discusses the current status of nanofiber and explores the benefits of various research works and concludes their results.
Original languageEnglish (US)
Pages (from-to)379-387
Number of pages9
JournalJournal of Drug Delivery Science and Technology
Volume43
DOIs
StatePublished - Feb 1 2018
Externally publishedYes

ASJC Scopus subject areas

  • Pharmaceutical Science

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